中西医结合治疗老年慢性阻塞性肺疾病急性加重期的临床疗效

Clinical Effects of Integrative Medicine in Treating Chronic Obstructive Pulmonary Disease of Senile Patients at Acute Exacerbation

目的:观察中西医结合治疗老年患者慢性阻塞性肺部疾病(COPD)加重期的临床疗效。方法:将COPD急性加重期年龄≥65岁患者84例随机分为2组,对照组接受常规西药治疗,试验组在常规西药治疗的基础上根据患者自身情况给予自拟健脾清肺化痰方剂,持续治疗3周比较治疗前后2组患者的临床疗效及动脉血氧分压(PO2)、动脉血二氧化碳分压(PCO_2)的变化情况。结果:试验组总有效率为92.86%,对照组为80.95%,2组比较差异具有统计学意义(P=0.026)。试验组患者治疗后PO2明显升高,PCO_2明显下降,对照组改变并不明显。试验组患者治疗后PO2较治疗前明显增加,治疗前后比较差异具有统计学意义(P=0.019),与对照组治疗后相比明显增高(P<0.05)。试验组患者治疗后PCO_2较治疗前明显降低(P<0.01),且较对照组降低明显(P=0.021)。结论:中西医结合治疗可有效提高老年患者COPD急性加重期的临床疗效,明显改善患者的血气指标,提高肺通气功能。

Objective： To investigate curative effects of integrative medicine in treating chronic obstructive pulmonary disease （COPD） of senile patients at acute exacerbation. Methods： All 84 COPD patients older than 65 years at acute exacerbation were randomized into two groups, the control group accepted routine western medicine, and the experiment group received selfmade JianPi QingFei HuaTan prescription according to the conditions of the patients on the basis of routine western medicine, clinical effects of both groups, the changes of PO2 and PCO2 were compared before and after treating after treating for three weeks consecutively. Results： Total effective rate of the ex- periment group was 92.86%, higher than 80.95% of the control group, and the difference had statistical meaning （P=0.026）. After treating, PO2 rose notably, and PCO2 decreased significantly in the patients of the experiment group, while the indexes of the control group changed insignificantly. PO2 increased after treating compared with before treating obviously in the experiment group, and there was statistical difference between before and after treating （P=0.019）, it increased remarkably compared with after treating in the control group （P〈0.05）. PCO2 decreased after treating compared with before treating in the experiment group （P〈0.01）, it decreased notably compared with the control group （P=0.021）. Conclusion： Integrative medicine therapy could effectively improve clinical effects of COPD of senile patients at acute exacerbation, obviously improve blood gas indexes of the patients and raise pul- monary ventilation function.