养心复脉汤对阵发性房颤患者左房功能及血清hs-CRP表达的影响

Effects of YangXin FuMai Tang on the Expressions of Serum hs-CRP and Left Atrial Function of the Patients with Paroxysmal Atrial Fibrillation

目的：探讨养心复脉汤对阵发性房颤患者左房功能及血清hs-CRP表达的影响。方法：将阵发性房颤患者70例随机分为观察组和对照组各35例。对照组患者给予西药治疗,观察组患者在对照组治疗的基础上给予养心复脉汤治疗,疗程均为3个月。观察并记录2组患者痊愈、显效、有效、无效及治疗前后中医证候积分、房颤持续时间与心室率、血清hs-CRP含量的变化。结果：有效率观察组为88.6%,对照组为57.1%,2组比较差异有统计学意义（χ~2=7.224,P=0.007）;中医证候积分、房颤持续时间与心室率、血清hs-CRP治疗前2组患者比较差异无统计学意义（P〉0.05）,治疗后2组患者各指标均较治疗前下降,差异有统计学意义（P〈0.05）,其中观察组的中医证候积分、血清hs-CRP低于对照组（t=5.229,P=0.000;t=2.415,P=0.016）,房颤持续时间与心室率组间比较差异无统计学意义（P〉0.05）。结论：养心复脉汤治疗阵发性房颤可显著提高患者治疗效果,改善中医证候积分,降低房颤持续时间与心室率,降低血清hs-CRP的表达。

Objective： To discuss the effects of YangXin FuMai Tang on left atrial function and serum hs-CRP expressions of the patients with paroxysmal atrial fribrillation （PAF）. Methods： Seventy patients were randomized in- to the observation group and the control group, 35 cases each group. The patients in the control group accepted west- ern medicine, and the ones in the observation group took YangXin FuMai Tang on the foundation of the treatment the control group received, one course of the treatment was three months. The contents of serum hs-CRP, ventricular rate （VR）, atrial fibrillation duration, TCM syndrome integral before and after treating, cure rate, markedly effective rate, effective rate and ineffective rate of the patients in both groups were observed and recorded. Results： Effective rate of the observation group was 88.6%, higher than 57.1% of the control group, and the difference noted statistical meaning （X^2=7.224, P=0.007）; the difference had no statistical meaning in the comparisons of TCM syndrome integral, atrial fibrillation duration, VR and the contents of serum hs-CRP before treating （P〉0.05）, these indexes de- creased after treating notably compared with before treating in both groups, and the difference showed statistical meaning （P〈0.05）, and TCM syndrome integral and the level ofhs-CRP of the observation group were lower than these of the control group apparently （t=5.229, P=0.000; t=2.415, P=0.016）, the difference had no statistical meaning in the comparisons of atrial fibrillation duration and VR between both groups （P〉 0.05）. Conclusion： YangXin FuMai Tang in treating PAF could significantly improve therapeutic effects of the patients and TCM syndrome integral, and reduce atrial fibrillation duration and VR, as well as the expressions of serum hs-CRP.