喷砂与手器刮治对龈下菌斑的清除效果及其对白细胞介素、MMP8/TIMP1含量的影响

Clearance effect of sandblasting and hand scaling on subgingival plaque and on interleukin and MMP8 / TIMP1 levels

目的：研究喷砂与手器刮治对龈下菌斑的清除效果及其对白细胞介素1/6/8/10、MMP8/TIMP1含量的影响。方法：选择2012年5月-2015年10月在广东省东莞市塘厦镇塘厦医院治疗的龈下菌斑患者40例进行研究,左半口的龈下菌斑进行手器刮治并作为手器刮治组,右半口的龈下菌斑进行喷砂刮治并作为喷砂组,治疗前后评估探诊深度（PD）、探诊出血（BOP）并计算牙周袋闭合百分比;治疗后采集龈沟液并测定白细胞介素1/6/8/10、MMP8/TIMP1的含量。结果：治疗后7 d和30 d时,两组的PD和BOP百分比均低于治疗前、牙周袋闭合百分比高于治疗前（P〈0.05）且喷砂组治疗后的PD和BOP百分比均低于手器刮治组、牙周袋闭合百分比高于手器刮治组（P〈0.05）;治疗后7 d时,喷砂组龈沟液中IL-1、-6、-8、MMP8的含量以及MMP8/TIMP1的比例显著低于手器刮治组,IL-10、TIMP1的含量显著高于手器刮治组。结论：喷砂刮治对龈下菌斑的清除效果优于手器刮治,能够通过调节白细胞介素1/6/8/10、MMP8/TIMP1含量的方式来减轻牙周组织炎症以及牙槽骨吸收。

Objective： To study the clearance effect of sandblasting and hand scaling on subgingival plaque and their effect on interleukin 1 /6 /8 /10 and MMP8 / TIMP1 levels. Methods： A total of 40 patients with subgingival plaque were selected for study,subgingival plaque of left half mouth received hand scaling and was included in hand scaling group,subgingival plaque of right half mouth received sandblasting scaling and was included in sandblasting group,probing depth（ PD） and bleeding on probing（ BOP）were assessed and the percentage of closed periodontal pocket was calculate before and after treatment; gingival crevicular fluid was collected after treatment to determine interleukin 1 /6 /8 /10 and MMP8 / TIMP1 levels. Results： Seven days and 30 days after treatment,PD and BOP percentage of both groups were lower than those before treatment and the percentage of closed periodontal pocket were higher than those before treatment（ P〈0. 05）,the PD and BOP percentage of sandblasting group after treatment were lower than those of hand scaling group and the percentage of closed periodontal pocket was higher than that of hand scaling group（ P〈0. 05）; 7 days after treatment,IL-1,-6,-8 and MMP8 levels and MMP8 / TIMP1 ratio in gingival crevicular fluid of sandblasting group were significantly lower than those of hand scaling group while IL-10 and TIMP1 levels were significantly higher than those of hand scaling group.Conclusion： Sandblasting scaling has better clearance effect on subgingival plaque than hand scaling,and can adjust the interleukin1 /6 /8 /10 and MMP8 / TIMP1 levels to relieve periodontal tissue inflammation and alveolar bone resorption.