旁正中微创切口与开放切口TLIF治疗单节段腰椎退行性疾病的创伤程度及脊髓功能评估被引量：6

Assessment of the trauma degree and spinal cord function of para-median minimally invasive and open TLIF for single segmental lumbar degenerative disease

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摘要目的:研究旁正中微创切口与开放切口TLIF治疗单节段腰椎退行性疾病的创伤程度及其对脊髓功能的影响。方法:选择78例在陕西省西安市红会医院接受TLIF治疗的单节段腰椎间盘突出症患者作为研究对象并随机分为两组,微创组接受旁正中微创切口TLIF、开放组接受开放切口TLIF。比较两组患者围手术期血清中氧化应激指标、疼痛介质含量及脊髓功能。结果:手术后1d、3d时,微创组患者血清中SOD、GSH-Px、SP的含量显著高于开放组,MDA、AOPP、NO、β-EP、PGE2、CGRP的含量显著低于开放组;手术后1周时,两组患者腓总神经、胫神经的NCV、DL与手术前比较无差异;手术后4周、16周时,两组患者腓总神经、胫神经的NCV均高于手术前、DL均低于手术前且微创组患者腓总神经、胫神经的NCV显著高于开放组、DL显著低于开放组。结论:旁正中微创切口TLIF治疗单节段腰椎退行性疾病的创伤程度较小且术后脊髓功能恢复更为理想。 Objective： To study the trauma degree of para-median minimally invasive and open TLIF for single segmental lumbar degenerative disease and the effect on spinal cord function. Methods： A total of 78 patients with single segmental lumbar disc herniation who received TLIF treatment in our hospital were selected as the research subjects and randomly divided into two groups,minimally invasive group received para-median minimally invasive TLIF and open group received open TLIF. Perioperative serum levels of oxidative stress indicators and pain mediators as well as spinal cord function were compared between two groups. Results： 1 d and3 d after operation,serum SOD,GSH-Px and SP levels of minimally invasive group were significantly higher than those of open group,and MDA,AOPP,NO,β-EP,PGE2 and CGRP levels were significantly lower than those of open group; 1 week after operation,NCV and DL of common peroneal nerve and tibial nerve of two groups were not different from those before operation; 4 weeks and 16 weeks after operation,NCV of common peroneal nerve and tibial nerve of both groups were higher than those before operation while DL were lower than those before operation,and NCV of common peroneal nerve and tibial nerve of minimally invasive group were significantly higher than those of open group while DL were significantly lower than those of open group. Conclusions： The trauma degree of paramedian minimally invasive TLIF for single segmental lumbar degenerative disease is less and the postoperative spinal cord function recovery is more ideal.

作者郑博隆贺宝荣杨小彬杨明闫亮白小帆郝定均

机构地区陕西省西安市红会医院脊柱外科

出处《海南医学院学报》 CAS 2016年第18期2160-2162,2166,共4页 Journal of Hainan Medical University

基金国家青年自然基金(81401843)~~

关键词腰椎间盘突出症经椎间孔腰椎椎体间融合术旁正中微创切口氧化应激脊髓功能 Transforaminal lumbar interbody fusion Para-median minimally invasive incision Lumbar disc herniation Oxidative stress Spinal cord function

分类号 R687.3 [医药卫生—骨科学]

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