血清SCC-Ag、CD105联合检测在宫颈癌早期诊断中的临床意义

Clinical significance of serum SCC-Ag combined with CD105 in patients with cervical cancer during early stage diagnosis

目的:探讨血清鳞状细胞癌抗原(SCC-Ag)、内皮因子(CD105)联合检测在宫颈癌早期诊断中的临床意义,为宫颈癌的早期诊断和临床治疗提供新思路。方法:选取74例宫颈癌患者为宫颈癌组,同时选取同期入院治疗的子宫肌瘤患者52例为正常宫颈组,清晨空腹条件下采集两组患者血清样本,采用酶联免疫法(ELISA)法检测两组患者血清SCC-Ag、CD105水平,采用t检验分析两组患者血清SCC-Ag、CD105水平变化,比较宫颈癌患者不同TMN分期及术后淋巴结转移与非淋巴结转移患者血清SCC-Ag、CD105水平变化,并应用Pearson相关分析法进行相关性分析。结果:ELISA检测结果发现,与正常宫颈组患者比较,宫颈癌组患者血清SCC-Ag和CD105水平升高,差异具有统计学意义(P<0.05)。与宫颈癌患者中TMN分期Ⅰ期比较,Ⅱ期患者SCC-Ag和CD105水平升高,Ⅲ、Ⅳ期患者血清SCC-Ag和CD105水平升高,差异具有统计学意义(P<0.05)。与Ⅱ期患者比较,Ⅲ、Ⅳ期患者血清SCC-Ag和CD105水平升高,差异具有统计学意义(P<0.05)。宫颈癌手术患者中,与非淋巴转移者比较,淋巴转移者血清SCC-Ag和CD105水平升高,差异具有统计学意义(P<0.05)。Pearson相关分析结果显示,SCC-Ag与CD105呈明显正相关(r=0.547,P<0.05)。结论:宫颈癌患者中血清SCC-Ag、CD105水平显著升高,两者联合检测在宫颈癌早期诊断中具有重要的临床应用价值,特别对宫颈癌分期及淋巴转移具有临床指导意义,值得临床借鉴。

Objective： To invest the clinical significance of serum SCC-Ag combined with CD105 in patients with cervical cancer during the early stage diagnosis. Methods： A total of 74 cases of cervical cancer were selected as cervical cancer group,and 52 cases of fibroid were selected as normal cervical group,these serum samples were collected on the morning by the condition of limosis,SCC-Ag and CD105 were checked by ELISA method,SCC-Ag and CD105 of two groups were analysed by t-test,and to compare SCCAg and CD105 in different TMN staging,lymph gland metastasis and non lymph gland metastasis in patients with cervical cancer,the correlation analysis was used by Pearson correlation analysis method. Results： These results from ELISA method showed that comparing with normal cervical group,the SCC-Ag and CD105 of cervical cancer group was significantly increased（ P〈0. 05）. Comparing with Ⅰperiod of TMN staging,SCC-Ag and CD105 of Ⅱ period was significantly,Ⅲ,Ⅳ period significantly increased（ P〈0. 05）.Comparing with Ⅱperiod,SCC-Ag and CD105 of Ⅲ,Ⅳ period was significantly increased（ P〈0. 05）. Comparing with non lymph gland metastasis,SCC-Ag and CD105 of lymph gland metastasis was significantly increased in cervical cancer with surgical treatment（ P〈0. 05）. According to pearson correlation analysis,SCC-Ag and CD105 were positively correlated（ r = 0. 547,P〈0. 05）. Conclusions： SCC-Ag and CD105 in patients with cervical cancer increase highly,it has important clinical value that of serum SCC-Ag combined with CD105 in the early diagnosis of cervical cancer,especially it has clinical guiding significance to staging and lymph gland metastasis of cervical cancer,and it is worthy of clinical reference.