摘要
多重药理学(polypharmacology)着重对两个方面进行研究:1)由药物分子脱靶效应(off-target)导致的药物毒副作用或不良反应;2)利用药物分子同时调节疾病网络系统中的多个靶点,针对复杂性疾病进行治疗。本文综述多重药理学这两个方面的新近研究进展,介绍新技术在多重药理药物发现过程中的应用。
Polypharmacology describes the activity of compounds at multiple targets.There are two aspects involved in polypharmacology ：1） Polypharmacology can lead to adverse effects due to off-target interaction profiles for drugs.2） Polypharmacological drugs that impact multiple targets simultaneously are better at controlling complex disease systems and are less prone to drug resistance.This reviewsummarizes the recent progress of polypharmacology and introduces some novel techniques and their applications in drug discovery.
出处
《中国药物化学杂志》
CAS
CSCD
2016年第4期342-347,共6页
Chinese Journal of Medicinal Chemistry
基金
国家重点基础研究发展计划项目(973计划
2015CB931804)
关键词
多重药理学
不良反应
多靶点
polypharmacology
adverse effects
multiple targets
