急性淋巴细胞性白血病患者血清及脑脊液胰岛素及白细胞介素相关指标的变化研究

Study on change of serum and cerebrospinal fluid insulin and interleukin related indexes of patients with acute lymphatic leukemia

目的探究急性淋巴细胞性白血病患者血清及脑脊液胰岛素及白细胞介素相关指标的变化情况。方法选取2011年10月-2015年8月本院收治的57例急性淋巴细胞白血病患者为观察组,同时期体检健康的57名同龄者为对照组。将两组的血清、脑脊液胰岛素及白细胞介素相关指标进行检测和比较,另比较观察组中不同FAB分型者的血清及脑脊液检测结果。结果观察组的血清及脑脊液白细胞介素2(IL-2)均低于对照组,其他血清及脑脊液白细胞介素相关指标均高于对照组,血清胰岛素1号增长因子(IGF-1)及胰岛素样生长因子结合蛋白3(IGFBP-3)均低于对照组,血清胰岛素2号增长因子(IGF-2)高于对照组,脑脊液胰岛素相关指标均高于对照组,且不同FAB分型患者的血清及脑脊液检测结果也有明显差异,差异有统计学意义(P<0.05)。结论急性淋巴细胞性白血病患者血清及脑脊液胰岛素及白细胞介素相关指标均呈现明显异常的状态,且不同FAB分型患者的检测结果差异也较为明显,因此认为对此类患者进行上述指标检测的价值较高。

Objective To study the change situation of serum and cerebrospinal fluid insulin and interleukin related indexes of patients with acute lymphatic leukemia. Methods From October 2011 to August 2015, 57 patients with acute lymphatic leukemia in our hospital were selected as the observation group, and 57 healthy persons of the same age with the health examination at the same time were selected as the control group. Then the serum and cerebrospinal fluid insulin and interleukin related indexes of two groups were respectively detected and compared. The serum and cerebrospinal fluid detection results of the observation group with different FAB types were compared too. Results The serum and cerebrospiual fluid IL-2 of the observation group were both lower than those of the control group, and other serum and cerebrospinal fluid interleukin related indexes were all higher than those of the control group. Serum IGF-1 and IGFBP-3 levels were all lower than those of the control group, serum IGF-2 level was highent （P 〈 0.05）.Conclusions The serum and cerebrospinal fluid insulin and interleukin related inr than that of control group. Cerebrospinal fluid insulin related indexes were all higher than those of control group, and the senun anti eerebrospinal fluid detection results of observation group with different FAB types had obvious differences, and the differences were all significadexes of patients with acute lymphatic leukemia shows obviously abnormal state anti the detection results＇differences of patients with different FAB types are obvious too, so those detection indexes all have higher detection value for the patients.