幽门螺杆菌感染对冠心病患者冠状动脉病变程度与血清Ghrelin/obestatin比值的影响

Influence of Helicobacter pylori infection on the severity of coronary artery lesions and serum Ghrelin/obestatin ratio in patients with coronary heart diseases

目的探讨幽门螺杆菌(Helicobacter pylori,H.pylori)感染与冠心病患者冠状动脉病变程度和血清Ghrelin/obestatin比值之间的关系。方法选取2013年1月至2014年10月行冠状动脉造影确诊冠心病患者116例作为冠心病组,选取同期健康体检人员80例作为对照组。对所有患者的冠状动脉病变程度进行Gensini评分,运用14 C尿素呼气试验方法测定H.pylori感染情况,测定血清Ghrelin和obestatin水平,分析H.pylori感染与冠状动脉病变程度、血清Ghrelin/obestatin比值之间的关系。结果冠心病组H.pylori感染阳性率明显高于对照组,差异有统计学意义(P<0.05)。H.pylori感染阳性组Gensini积分明显高于H.pylori感染阴性组,差异有统计学意义(P<0.05);H.pylori感染阳性组Ghrelin/obestatin比值明显低于H.pylori感染阴性组,差异有统计学意义(P<0.05)。结论 H.pylori感染能够加重冠心病患者冠状动脉病变程度,引起Ghrelin/obestatin比值异常升降低。H.pylori感染与冠心病发生发展密切相关。

Objective To explore the influence of Helicobacter pylori （H. pylori） infection on the severity of coronary artery lesions and serum Ghrelin/obestatin ratio in patients with coronary heart diseases. Methods 116 cases of coronary heart diseases diagnosed by coronary arteriography from January 2013 to October 2014 were selected as the coronary heart disease group, with 80 healthy subjects who accepted physical examination during the same time period as the control group. The severity of coronary artery lesions were assessed using Gensini scores; ^14C-urea breath test was used to confirm H. pylori infection; the levels of serum Ghrelin/obestatin ratio were determined; the relationships between H. pylori infection and severity of coronary artery lesion, and serum Ghrelin/obestatin ratio were analyzed. Results The positive rate of H. pylori infection in Coronary heart disease group was significantly higher than that in the control group （P〈0.05）. The Gensini scores of patients with H. pylori infection were significantly higher than those in non H. pylori infection group （P〈0.05）. The ghrelin/obestatin ratio in H. pylori infection group was significantly higher than that in non H. pylori infection group （P〈0.05）. Conclusion H. pylori infection can aggravate the severity of coronary artery lesion and decrease the Ghrelin/obestatin ratio in patients with coronary heart diseases, suggesting that H. pylori infection is closely related to the development and occurrence of coronary heart disease.