摘要
目的分析耐多药肺结核患者耐药性产生的危险因素。方法收集涂阳肺结核患者823例的痰标本进行罗氏培养及药敏试验,根据药敏结果将至少同时对利福平及异烟肼耐药患者作为耐多药组(105例),其余患者为对照组(718例),分析耐多药形成原因。结果单因素分析显示,耐多药组和对照组性别构成比、家庭收入、BMI、接受化疗及不正规治疗情况比较差异有统计学意义(P<0.05)。多因素分析显示,复治、家庭收入偏低、接受不正规治疗为肺结核患者耐多药产生的危险因素(P<0.05)。结论需重视结核病患者的健康教育和经济救助,加强对有传染性的耐多药结核患者的隔离管理。
Objective To analyze the risk factors for multidrug-resistance of the patients with pulmonary tuberculosis. Methods On the basis of Roche culture and drug susceptibility test, 823 patients with smear-positive pulmonary tuberculosis were assigned into two groups of A （with multidrug-resistance,105 cases） and B（without multidrug-resistance, 718 cases）. The risk factors for multidrug-resistance were analyzed. Results Single factor analysis showed that the variables of gender, body mass index, history of chemotherapy, irregular treatment and family income were significantly different between two groups（P〈0. 05）. Multiple factors analysis showed that repeated therapy,low family income and irregular treatment were the risk factors for multidrug-resistance （P〈0.05）. Conclusion Attention should be paid to the health education and social aid in the patients with tuberculosis infection. The isolation management of the patients with multidrug-resistance needs to be strengthened.
出处
《江苏医药》
CAS
2016年第16期1776-1778,共3页
Jiangsu Medical Journal
基金
徐州市科技计划项目(XM12B057)
关键词
肺结核
耐多药
Pulmonary tuberculosis
Multidrug-resistance
