阿维A与氨甲蝶呤治疗重度斑块型银屑病的疗效

Effect of acitretin and methotrexate on treatment of severe plaque psoriasis

目的:观察阿维A与氨甲蝶呤治疗重度斑块型银屑病的疗效。方法:54例确诊为斑块型银屑病的患者被分为阿维A组(32例,口服阿维A30 mg,每日1次)和氨甲蝶呤组(22例,口服氨甲蝶呤15 mg,每周1次),均外用卡泊三醇软膏和硼酸软膏,疗程8周。以银屑病面积和严重度指数(psoriasis area and severity index,PASI)作为观察指标,比较两种药物的疗效。结果:治疗后,阿维A组和氨甲蝶呤组PASI评分均较治疗前下降(P<0.001),PASI评分改善率和PASI评分有效率在两组间比较差异均无统计学意义(均P>0.05)。结论:阿维A或氨甲蝶呤治疗重度斑块型银屑病均有效,且疗效相当。

Objective： To evaluate effects of acitretin and methotrexate on treatment of severe plaque psoriasis. Methods： A total of 54 patients were treated with either acitretin （32 patients; 30 mg per day） or methotrexate （22 patients; 15 mg per week） for 8 weeks. The therapeutic effects of the two drugs were evaluated according to the psoriasis area and severity index （PASI）. Results： After 8 weeks of treatment, the score of PASI decreased in both the acitretin group and the methotrexate group （P〈0.001）. However, there was no significant differences neither in the percentage reduction in the PASI score nor in PASI response rate between the two groups （P〉0.05）. Conclusion： Acitretin and methotrexate exert similar therapeutic effect in severe plaque psoriasis.