北京地区不同人群柯萨奇病毒A16型和肠道病毒71型感染状况调查

Serological survey of coxsackie virus A16 and enterovirus 71 infections among different population groups in Beijing

目的了解北京地区不同人群柯萨奇病毒A16型（coxsachievirus A16,Cox A16）和肠道病毒71型（enterovirus 71,EV71）感染状况。方法 2012年对北京9区进行整群随机抽样,采集血样,开展血清流行病学调查。用酶联免疫吸附实验检测血清中抗Cox A16和抗EV71免疫球蛋白G（immunoglobulin G,Ig G）和免疫球蛋白M（immunoglobulin M,Ig M）抗体。结果 2 140名被研究人群中,抗EV71 Ig G和Ig M阳性率分别为27.0%和1.6%,抗Cox A16 Ig G和Ig M的阳性率分别为48.5%和4.2%,抗EV71 Ig M与抗Cox A16 Ig M同时阳性阳性率为0.7%,抗EV71 Ig G与抗Cox A16 Ig G同时阳性阳性率为17.2%。各年龄组抗EV71 Ig M、Ig G阳性率、抗Cox A16 Ig M、Ig G阳性率、抗EV71 Ig M和抗Cox A16 Ig M同时阳性的阳性率、抗EV71 Ig G和抗Cox A16 Ig G同时阳性阳性率差异均有统计学意义（均有P〈0.05）。1~岁组抗EV71 Ig M阳性率最高,5~岁组抗Cox A16 Ig M阳性率最高,10~岁组抗EV71Ig G和20~岁组抗Cox A16 Ig G阳性率最高。女性抗Cox A16 Ig G阳性率高于男性。结论低龄组儿童是手足口病防控的重点人群,手足口病防控措施制定应考虑地域分布因素。

Objective To understand the infection status of coxsackievirus A16（ Cox A16） and enterovirus 71（ EV71） among different population groups in Beijing. Methods A cluster random sampling was performed in nine districts of Beijing in 2012. Blood samples were collected and serological survey was conducted with enzyme-linked immunosorbent assay（ ELISA） to detect levels of anti-EV71,anti-Cox A16 immunoglobulin G（ Ig G） and immunoglobulin M（ Ig M）. Results A total of 2 140 people were enrolled in this study. The seropositive rates of anti-EV71 Ig G and Ig M were 27. 0% and 1. 6% respectively. The positive rates were 48. 5% and 4. 2% for anti-Cox A16 Ig G and Ig M,respectively. The positive rate of both anti-EV71 and Cox A16 Ig M positive was 0. 7%. The positive rate of both anti-EV71 and CoxA16 Ig G positive was 17. 2%. Significant difference of positive rate was observed among different age groups. The age group of 1-4 years old showed the highest positive rate for anti EV71 Ig M. The age group of 5-9 years old showed the highest positive rate of anti-Cox16 Ig M. The age group of 10-14 years old showed the highest positive rate of anti-EV71 Ig G.The age group of 20-24 years old showed the highest positive rate of anti-Cox A16 Ig G. The positive rate of anti-Cox A16 Ig G was significantly higher in female compared with that in male. Conclusions Young children should be focused by the hand foot and mouth disease（ HFMD） prevention and control,and geographical distribution factors should be considered during the development of HFMD prevention and control strategies.