狼疮静联合泼尼松治疗系统性红斑狼疮临床疗效

Efficacy of Lupus Prescription Combined with Prednison on Treatment of Systemic Lupus Erythematosus

目的:观察狼疮静治疗系统性红斑狼疮(SLE)的远期临床疗效及作用,并进一步阐述其方剂组成规律,探索并丰富SLE中医药治疗体系。方法:运用回顾性、多中心试验方法,将300例活动性SLE患者随机分为治疗组和对照组,各150例。治疗组采用激素泼尼松加中药狼疮静联合治疗,对照组采用单纯激素治疗,两组疗程均为6个月。观察两组治疗前后24h尿蛋白量、免疫指标、狼疮活动评分的变化以及激素副作用的发生率、半年内的复发情况。结果:治疗后,治疗组对24 h尿蛋白量、红细胞沉降率(ESR)、血清补体C4含量的改善明显优于对照组(P<0.05),其余指标的改善程度无显著性差异;治疗组狼疮活动评分较对照组明显降低(P<0.05);随访中,治疗组的复发率及激素副作用发生率较对照组明显降低(P<0.05)。结论:狼疮静治疗SLE远期疗效显著,尤其在调节免疫、有效促进激素撤减、减轻西药的毒副作用、提高治疗效果等方面作用突出。

Objective： To investigate the long-term clinical efficacy of lupus prescription on systemic lupus erythematosus（ SLE）,and further clarify the composition rules of the prescription,explore and enrich the theory of SLE in traditional Chinese medicine treatment system. Method： Retrospective,multi center test method was used,and 300 active SLE patients were randomly divided into treatment group and control group,150 cases in each group. Patients in treatment group received hormone Prednison ＋ Chinese herbal medicine lupus prescription,while patients in control group only received hormone therapy. The treatment was 6 months for both groups. Both groups were observed for changes of 24 h urine protein quantity,immune index,lupus activity scores before and after treatment,as well as the incidence of adverse effects,and the recurrence of the disease within half an year.Result： After treatment,the improvement of 24 h urinary protein,C4 and erythrocyte sedimentation rate（ ESR） in treatment group was significantly better than that in control group（ P〈0. 05）. There was no significant difference in the improvement of the other indicators. The lupus activity scores in treatment group were significantly lower than those in control group（ P〈0. 05）. The incidence of side effects and recurrence rate of the disease in the treatment group were significantly lower than those in control group（ P〈0. 05）. Conclusion： Chinese herbal medicine lupus prescription has obvious long-term efficacy in treatment of SLE, especially in regulating immune function,promoting withdrawal of hormone,lessening the side effects of Western medicine and improving the therapeutic effect.