超早期尿激酶静脉溶栓治疗急性脑栓塞64例疗效分析

Therapeutic effect analysis of ultra-early intravenous thrombolysis with urokinase in 64 patients with acute cerebral embolism

目的观察超早期尿激酶静脉溶栓治疗急性脑栓塞的临床效果。方法选择我院收治的64例急性脑栓塞患者为研究对象,随机分为对照组和观察组。对照组采用常规治疗,观察组采用超早期尿激酶静脉溶栓治疗,比较2组治疗效果、治疗前后神经功能缺损改善情况。结果观察组总有效率达100%,显著高于对照组的62.5%。观察组治疗后24h、2周神经功能缺损评分显著优于对照组。2组不良反应发生率差异无统计学意义(P>0.05)。结论超早期尿激酶静脉溶栓治疗急性脑栓塞疗效确切,安全可靠,值得临床推广应用。

Objective To observe the clinical effect of ultra-early intravenous thrombolytic therapy with urokinase for the treatment of acute cerebral embolism. Methods Sixty-Four cases with acute cerebral embolism in our hospital were randomly divided into control group and observation group. The control group received conventional treatment and the observation group received ultra-early intravenous tbrombolytic therapy with urokinase. The therapeutic effects and neurological deficits before and after treatment between two groups were compared. Results The total effective rate of the observation group was 100%, significantly higher than 62.5% of the control group. At 24 hours and at the two weeks after treatment, the neurological deficit scores in the observation group were significantly better than those in the control group. The incidence of adverse reactions of the two groups had no statistically significant difference（P〉0.05）. Conclusion Ultra-early intravenous thrombolysis with urokinase for acute cerebral embolism is curative, safe and reliable, which is worthy of clinical popularization and application.