激活素A与心脏疾病关系的研究进展

Research Progress of Activin A and Heart Diseases

激活素A与急性及慢性炎症有关并可用于预测疾病的严重性,激活素A也参与纤维化和凋亡等疾病的病理过程。在不同的疾病模型中,抑制激活素A能够减弱机体的炎症反应、逆转纤维化及降低病死率。心脏疾病的发生、发展及预后与炎症、纤维化和凋亡有密切关系,同时激活素A在很多心脏疾病中发挥重要作用。因此,激活素A已经成为诊断和治疗心脏疾病的一种工具。

Activin A is related to acute and chronic inflammation and can be used to predict the severity of the diseases. Activin A is also involved in the pathological process of fibrosis and apoptosis. In various dis- eases models,inhibition of activin A can attenuate inflammation, fibrosis, apoptosis and mortality. The devel- opment and prognosis of heart diseases are tightly associated with inflammation, fibrosis and apoptosis, and activin A plays an important role in many heart diseases. Therefore activin A is regarded as a diagnostic and therapeutic tools in various heart diseases.