青蒿琥酯对肝纤维化相关分子机制的影响研究进展

Progress in Research on the Effects of Artesunate on the Molecular Mechanism of Liver Fibrosis

肝纤维化是各种慢性肝炎发展为肝硬化必经的病理阶段,同时也是向肝癌发展的中间环节。肝星状细胞(HSC)是肝纤维化发生、发展的关键细胞,抑制HSC的活化与增殖是预防和治疗肝纤维化的主要策略之一。青蒿琥酯是青蒿素的衍生物,其具有抗肝纤维化、肝硬化和肝癌的作用,能够使活化的HSC发生凋亡,促凋亡机制是通过抑制细胞外基质的产生以及激活或抑制一些信号通路从而发生一定的级联效应。目前青蒿琥酯可作用于HSC中的信号通路有:转化生长因子β_1/Smad、核因子κB、Wnt/β-catenin及肿瘤坏死因子α介导的信号通路等。

Liver fibrosis is the necessary pathological stage of all kinds of chronic hepatitis developing into liver cirrhosis ,and it is also the intermediate link to liver cancer. Hepatic stellate cell （HSC） is the key cell in the development of hepatic fibrosis, and it is one of the main strategies to prevent and treat hepatic fibrosis by inhibiting the activation and growth of HSC. Artesunate is a derivative of artemisinin, which is found it to have the role of anti-liver fibrosis, cirrhosis and cancer, and can promote apoptosis of the activated HSC through inhibiting the production of extracellular matrix and signaling pathways, including transforming growth factor-β1/Smad, nuclear factor-κB, Wnt/β-catenin signal pathway and tumor necrosis factor-α- induced fibrosis pathway, which together generate cascading effect.