非小细胞肺癌与腺苷酸活化蛋白激酶、核因子κB、环加氧酶2、前列腺素E_2的关系

Relationship between Non-small Cell Lung Cancer and Adenosine 5'-monophosphate-activated Protein Kinase,Nuclear Factor κB,Cyclooxygenase and Prostaglandin E_2

慢性炎症为肿瘤发生的关键促进因子,炎症相关基因腺苷酸活化蛋白激酶(AMPK)、核因子κB(NF-κB)、环加氧酶2(COX-2)、前列腺素E_2(PGE_2)在非小细胞肺癌(NSCLC)细胞增殖、凋亡、转移过程中起着重要作用,它们之间相互调节,启动相关信号通路,共同参与肿瘤细胞的发生、发展,促进NSCLC细胞的增殖和迁移。研究AMPK/NF-κB/COX-2/PGE_2在NSCLC发生、发展中的相互关系,可能为NSCLC的诊断、治疗及预后判断提供新的分子标志物,为NSCLC的三级预防奠定理论与实验基础。

Abstract： Chronic inflammation is a key tumor promoting factor,and inflammation-related genes adenosine-monophosphate-activated protein kinase （ AMPK ）, nuclear factor κB （ NF-κB ）, cyclooxygenase-2 （ COX-2 ） and prostaglandin E2 （ PGE2 ） play important roles in the proliferation, apoptosis and metastasis of non-small cell lung cancer（ NSCLC ） that their interactions and related signaling pathways are involved in the development and progression of tumor cells. They promote the proliferation and migration of NSCLC cells con- tinuously. The studies on AMPK,NF-κB, COX-2 and PGE2 in the development of NSCLC may provide new molecular markers of the diagnosis, treatment and prognosis, establishing theoretical and experimental basis for the tertiary prevention of NSCLC.