养血清脑颗粒治疗急性脑梗死的临床疗效

Study of the Influence of Yangxue Qingnao Granule on the Clinical Effect of Patients with Acute Cerebral Infarction

目的观察养血清脑颗粒治疗急性脑梗死的临床疗效。方法选取2014年5月至2015年5月保定市第一中心医院收治的急性脑梗死患者100例,采用随机数字表法分为观察组和对照组,各50例。患者均给予抗凝、调脂、营养神经以及支持等治疗,观察组在常规治疗的基础上加用养血清脑颗粒,1袋/次,3次/d,连续治疗4周。治疗前及治疗4周后对患者神经功能缺损、认知功能障碍、日常生活能力进行评定,同时检测患者凝血因子Ⅰ、全血比黏度、血浆比黏度变化情况。结果观察组治疗总有效率显著优于对照组[94.0%(47/50)比80.0%(40/50),P<0.05]。治疗前两组美国国立卫生院卒中量表(NIHSS)评分、日常生活能力量表(BI)评分比较差异无统计学意义(P>0.05);治疗4周后,观察组NIHSS评分、BI评分显著优于对照组[(7.4±0.8)分比(10.5±1.0)分,(75.3±5.8)分比(64.5±4.2)分,P<0.01];观察组凝血因子Ⅰ水平、全血比黏度、血浆比黏度显著优于对照组[(3.8±0.4)g/L比(4.0±0.3)g/L,(6.12±0.62)m Pa·s比(7.82±0.73)m Pa·s,(1.32±0.35)m Pa·s比(2.13±0.40)m Pa·s,P<0.01]。结论养血清脑颗粒治疗急性脑梗死临床疗效确切,可有效降低患者血黏度,保护缺血神经组织,促进神经功能恢复。

Objective To observe the irr[luence of yangxue qingnao granule on the clinical erect of patients with acute cerebral infarction. Methods Total of 100 patients with acute cerebral infarction admit- ted tO Baoding First Central Hospital from May 2014 to May 2015 were included in the study, and divided into an observation group and a control group according to the random number table method,50 cases in each group. All patients were treated with anticoagulation,lipid regulation, neurotrophic and support therapy, while the observation group was added with Yangxue Qinguao granule, I bag/time,3 times/day, continuously for 4 weeks. Before and 4 weeks after treatment, the neurologic impairment, cognitive impairment, daily life ability were assessed, and coagulation factor I, whole blood specific viscosity, and plasma specific viscosity were detected. Results The total effective rate of the observation group was significantly better than the control group [ 94. 0% （ 47/50 ） vs 80. 0% （ 40/50 ）, P 〈 0. 05 ]. The National Institute of Health Stroke Scale （NIHSS） score and Barthef Index （BI） score of the two groups had no significant differences before treatment,but sthe observation group w significantly better than the control group after 4 weeks of treatment [ （7. 4 ±0.8） scores vs （ 10.5 ± 1.0） scores, （75.3 ±5.8） scores vs （64.5±4.2） scores,P 〈0.01 ]. Coagulation factor I levels ,whole blood specific viscosity,plasma specific viscosity of the observation group were sig- nificantly better than the control group[ （3. 8±0. 4） g/L vs （4. 0±0. 3 ） g/L; （6. 12 ±0. 62） mPa·s vs （7. 82 ±0. 73） mPa·s; （ 1.32±0. 35） mPa·s vs （2. 13 ±0. 40） mPa·s; P 〈 0.01 ]. Conclusion Yangxue qinguao granule in treatment of acute cerebral infacetion has exact clinical curative effect, which can effectively reduce the blood viscosity,protect ischemic nerve tissue, and promote the recovery of neurological function of the patients.