干预胆碱M受体对药物成瘾的影响及其与多巴胺的关系

The effect of interference with muscarinic receptor on drug addiction and its relationship with dopamine

药物成瘾是一类精神及行为障碍,涉及到中枢神经系统的病变。毒蕈碱受体(Muscarinic receptor,M受体)属于胆碱能受体,分5种亚型。行为学研究表明,干预M受体能有效影响药物成瘾行为,但其神经机制还亟待探索。阿片类药物与精神活性药物均能激活中枢多巴胺系统,而M受体与多巴胺系统在多个脑区产生了交互作用。其中激动M2及M4受体抑制了多巴胺系统功能,而激动M5受体增强了多巴胺系统功能,与干预M2、M4、M5受体对药物成瘾行为的影响相对应。以上证据提示,干预M受体可能通过影响多巴胺系统对药物成瘾起作用。

Drug addiction is a disease with central nervous system dysfunction. Muscarinic receptor belong to cholinergic system, has five subtypes, M1-M5 receptors. Behavioral research show that interference with M receptor could affect drug addiction behavior. Both opioids and psychoactive drugs could active central DA system. And M receptor regulating dopamine system in various brain areas, implicate there is a potential way that M receptor affect addiction behavior through interaction with DA system. Activing M2 and M4 receptor could inhibit DA system activating, and active M5 receptor could facilitate DA system activating, in corresponding to the effect of intervened with M2, M4, M5 receptor in drug addiction behavioral research. These evidences prove that M receptor regulating DA system in drug addiction behavior, and M receptor could be new neural target for treatment of drug addiction.