卵巢低储备患者改良超长方案与微刺激方案助孕结局比较

Comparison of assisted reproduction technology results of modified ultra- long protocol and minimal stimulation protocol among patients with diminished ovarian reserve

目的通过分析卵巢储备功能下降(DOR)患者应用改良超长及微刺激方案促排卵的治疗结局,为DOR患者寻找一种最佳的治疗方案。方法回顾性分析2011年11月-2015年12月厦门市妇幼保健院采取改良超长及微刺激方案行IVF/ICSI助孕的DOR患者202例。根据治疗方案将患者分为两组:第1组(改良超长方案组)107例,第2组(微刺激方案组)95例。比较两组患者的治疗结局。结果两组患者年龄、不孕年限、BMI、基础FSH、AFC比较,差异无统计意义(P>0.05)。但改良超长方案组Gn用量、Gn天数、获卵数、可用胚数、优胚数、临床妊娠率、着床率显著高于微刺激方案组(P<0.05)。结论对于卵巢储备功能下降的患者,采用改良超长方案助孕可以获得较好的临床妊娠率,是值得推荐的一种治疗方案。

Objective To find the best protocol for women with diminished ovarian reserve by analyzing the assisted reproduction technology （ART） results of modified ultra-long protocol and minimal stimulation protocol among patients with diminished ovarian reserve （DOR） . Methods A total of 202 patients with DOR treated by IVF/ICSI through modified ultra-long protocol and minimal stimulation protocol respectively in the hospital from November 2011 to December 2015 were analyzed retrospectively, then the patients were divided into modified ultra-long protocol group （107 patients） and minimal stimulation protocol group （95 patients） according to treatment protocol. The treatment results in the two groups were compared. Results There was no statistically significant difference in age, duration of infertility, BMI, basic FSH, and AFC between the two groups （P〉0. 05） . The dose and application time of gonadotropin （Gn）, the number of retrieved oocytes, the number of available embryos, the number of good quality embryos, clinical pregnancy rate, and implantation rate in modified ultra-long protocol group were statistically significantly higher than those in minimal stimulation protocol group （P〈0. 05） . Conclusion For the patients with diminished ovarian reserve, modified ultra-long protocol can obtain high clinical pregnancy rate, which is worthy of recommendation.