摘要
CDX2是肠源特异性转录因子,它在胚胎发育及肠道分化中都是必需的。正常情况下,CDX2在胚胎时期和产后时期表达于从近端十二指肠到远端直肠的肠道上皮细胞的细胞核,或者表达于胃的肠上皮化生组织,但不会表达于正常成人的食管和胃上皮。CDX2的表达不仅与正常肠道黏膜的表型有关,还与肿瘤的分期及肠源性腺癌的预后有关。总之,CDX2在胃肠肿瘤的形成中具有重要作用。一些研究曾报道CDX2在人类结直肠癌和胃癌形成中具有肿瘤抑制作用,但CDX2在肠源性腺癌中的具体作用机制是十分复杂的,有待进一步研究。
CDX2 is an intestine-specific transcription factor essential for embryogenesis and differentiation of in-testines. CDX2 is normally present throughout embryonic and postnatal life within the nuclei of the intestinal epi-thelial cells in the proximal duodenum through the distal rectum and also abnormally in intestinal metaplasia ofthe stomach, but not in the normal epithelium of the esophagus and stomach in adults. CDX2 expression is associ-ated with not only intestinal mucin phenotypes, but also an early tumor stage and improved prognosis in patientswith adenocarcinomas of intestinal origin. In conclusion, CDX2 is important in carcinogenesis of the digestive tract.Several previous reports have suggested a tumor suppressive role for CDX2 in human colorectal and gastric carcino-genesis, but the CDX2 regulatory network is intricate and remains to be fully elucidated in adenocarcinomas of in-testinal origin.
出处
《生物技术通讯》
CAS
2016年第4期566-571,共6页
Letters in Biotechnology
