BRAP基因多态性与寻常型银屑病的相关性分析

Association study of BRAP gene polymorphism and clinical features of psoriasis vulgaris

目的分析BRAP基因rs3782886多态性与中国汉族人寻常型银屑病(PV)临床表型之间的关系。方法利用本研究团队前期全基因组外显子芯片测序分析Illumina Human610基因分型平台对16 876例PV患者和22 920例健康对照者的基因分型结果,分析病例组间和病例组与对照组间不同临床表型的基因型-临床表型之间的差异。结果遗传模式分析显示BRAP基因rs3782886在显性模型下对PV的发病作用影响最大(P<0.05)。分层分析结果表明BRAP基因rs3782886多态性与PV的发病类型相关(P<0.05)。未发现rs3782886与PV的其他表型包括发病年龄、家族史、疾病严重程度相关。结论 BRAP基因rs3782886多态性在中国汉族人群中不仅与PV发病风险相关,还与PV临床表型相关,特别是与PV的发病类型相关。

Objective To analyze the relationship between BRAP gene rs3782886 polymorphism and Chinese patients with psoriasis vulgaris in Chinese Han population of the clinical phenotype. Methods A total of 16 876 cases of psoriasis and 22 920 cases of healthy controls were derived from our previous whole exome array analysis in the Chinese Han population using Illumina Human 610 chips. SPSS 20. 0 software was used to analyze the difference between the genotype and clinical phenotype of patients with different clinical phenotypes between case group and control group. Results Analysis of the genetic pattern revealed that the most suitable model describing the association of BRAP gene rs3782886 polymorphism with psoriasis vulgaris was dominant model（ P〈 0. 05）. The results of stratified analysis showed that BRAP gene rs3782886 polymorphism was related to the type of psoriasis vulgaris（ P〈 0. 05）. However,we failed to observe any significant association of rs3782886 polymorphism with other sub-phenotype in psoriasis vulgaris. Conclusion This study suggests that BRAP gene rs3782886 polymorphism might not only play important roles in the development of psoriasis vulgaris,but also contributing to the type of psoriasis vulgaris.