阻塞性呼吸暂停低通气综合征患者RNFL厚度改变的Meta分析

Retinal nerve fiber layer thickness changes in obstructive sleep apnea / hypopnea syndrome: a Meta-analysis

目的系统评价阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者视网膜神经纤维层(RNFL)厚度是否变薄。方法电子检索辅以手工检索Pub Med、Web of Sciences和万方数据库收录的病例对照和队列研究。对于连续性变量结果,计算合并加权均数差(WMD)和95%可信区间(CI)。应用Rev Man 5.3软件统计分析。结果 7个符合要求文献纳入Meta分析。总体效应OSAHS组RNFL厚度比健康对照组薄;按OSAHS病情程度亚组分析:轻中度的OSAHS和对照组之间RNFL厚度差异无统计学意义;重度OSAHS患者和对照组RNFL厚度差异有统计学意义(P<0.05)。结论OSAHS患者RNFL厚度变薄。而且RNFL厚度变薄程度和OSAHS病情程度成正相关。

Objective To assess the retinal nerve fiber layer（ RNFL） thickness change in patients with obstructive sleep apnea-hypopnea syndrome（ OSAHS）. Methods Pummed,Web of Science,and Wanfang databases were searched to identify relevant cohort studies and case control studies about the correlation between OSAHS and RNFL thickness. The literatures in conference proceedings and some unpublicized articles were also retrieved. Two reviewers independently collected the data,assessed the quality,and conducted the Meta-analysis by using Rev Man 5. 3software. Results A total of 7 studies were included in this Meta-analysis. The results of Meta-analysis showed that the RNFL thickness was significantly thinner in the OSAHS group when compared with the control group（ WMD =-3. 42,CI =-5. 51 ^-1. 33,P〈 0. 001）. In the subgroup analysis stratified by the different grades of OSHAS.There were no significant differences in RNFL thickness between mild / moderate OSAHS and the control group（ P〉 0. 05）. However,compared with the controls,severe OSAHS group had significantly thinner RNFL thickness（ WMD =-5. 03,CI =-8. 99 ^-1. 06,P〈 0. 01）. Conclusion The RNFL thickness is thinner in OSAHS group. Between the severity of OSAHS and RNFL thickness shows a positive correlation.