女性乳腺密度与年龄及乳腺癌的相关性研究

Correlation research of female breast density types,age and breast cancer

目的探讨女性乳腺密度与年龄及乳腺癌的相关性。方法对符合纳入标准并自愿接受乳腺X线检查的5 006例女性,依据第四版ACR BI-RADS分类对乳腺密度进行分型,分析年龄分组、乳腺密度分型与乳腺癌间的关系。结果 5 006例受检女性平均年龄(44.22±8.09)岁。乳腺密度类型为脂肪型256例(5.11%),少量型726例(14.51%),多量型3719例(74.29%),致密型305例(6.09%)。不同乳腺密度类型患者间年龄分布差异有统计学意义(P<0.001)。各年龄组间乳腺密度类型分布差异有统计学意义(P<0.001)。病理诊断乳腺癌184例,平均年龄(51.26±10.15)岁。乳腺密度类型中乳腺癌发生百分比由高到低依次为脂肪型10.16%(26/256)、少量腺体型9.09%(66/726)、多量腺体型2.45%(91/3719)、致密腺体型0.33%(1/305)。乳腺癌患者在各年龄组间以及不同乳腺密度类型间差异有统计学意义(P<0.001)。结论年龄是影响女性乳腺密度的重要因素;较低乳腺密度类型女性患乳腺癌风险较为突出。

Objective To explore the relationship between the types of female breast density and age and breast cancer .Methods By accepting the digital mammography X -ray examination for 5 006 women cases and according to the ACR BI -RADS standard in the fourth edition ,the breast density assessment was quantified . We analysed the relationship between the breast density and age and breast cancer .Results In 5 006 cases,the average female age was between 44.22 ±8.09 years old,median age was 43 years old.The components of the breast density were fat type , small amount type , large amount type and compact type each count were 256 （5.11%）,726（14.51%）,3 719（74.29%）,305（6.09%）respectively.By dividing into different age -group to analyze the breast density,there was significant statistical differences of the breast density among age -groups（P〈0.001）.Among them the breast cancer were 184 cases.Age was between 51.26 ±10.15 years old.Breast cancer in each breast density were fat type 10.16%（26/256）,small amount type 9.09%（66/726）,large a-mount type 2.45%（91/3719）and compact type 0.33%（1/305）.There were statistical differences among age -groups and breast densities and breast （P〈0.001）.Conclusion Age plays a very important effects on the fe-male breast density .The lower breast density is a high risk factor to breast cancer occurrence .