MicroRNA和NF-κB与胃癌侵袭转移关系的研究进展

Research progress of the relationship between microRNA and NF-κB in the invasion and metastasis of gastric cancer

MicroRNA(miRNA)是一类对基因具有调控功能的内源性非编码小分子RNA,通过与靶mRNA的3′端非编码区序列特异结合对靶基因进行转录后水平的调控。细胞核转录因子Kappa B(Nuclear factor kappaB,NF-κB)是一种重要的核内转录因子,活化后能与某些基因上启动子区域的固定核苷酸序列结合而启动基因转录,参与胃癌的浸润及转移。近年来研究发现,miRNA不仅可通过调控下游靶基因NF-κB的表达参与肿瘤的侵袭和转移,其自身也受到NF-κB转录因子的调控。本文主要综述了microRNA与NF-κB在胃癌中的表达,以及它们通过相互调控基因的表达来影响胃癌细胞的侵袭和转移。

MiRNA is a class of small endogenous non -coding molecule RNA with regulatory functions , which regulates the target genes at the post -transcriptional level by binding with 3′untranslated regions （3′UTR） specifically.Nuclear factor kappaB（NF-κB）is a kind of significant intranuclear transcription factor .Being activ-ized,it easily combines with the fixed nucleotide sequence in promoter region to initiate gene transcription and participates in the invasion and metastasis of gastric cancer .Recent researches showed that miRNA not only influ-ences on tumor invasion and metastasis by regulating the expression of downstream target gene NF -κB,and itself also could be regulated by NF -κB transcription factors .This essay mainly narrates the expression of microRNA and NF-κB in gastric carcinoma ,and summarize the influence to the invasion and metastasis of gastric cancer cells by regulating thier expression interction .