白塞综合征与感染

Behcet＇s disease and infection

白塞综合征是一种病因不明的系统性血管炎,葡萄膜炎是其累及眼部的主要表现,不仅常见且病情重,治疗困难.研究表明该病的发生不仅与基因（如HLA-B51）有关,环境因素也起到了重要作用,如感染.随着微生物检测技术的提高,许多免疫性疾病被证实与微生物感染相关.作为一种以免疫系统功能紊乱为特征的疾病,白塞综合征与微生物感染的相关研究近年来受到越来越多关注.目前已报道与白塞综合征相关的微生物包括血链球菌、金黄色葡萄球菌、肠道菌群及单纯疱疹病毒等.为了解白塞综合征与感染的研究现状,本文对已有研究进行综述,以期为临床探索白塞综合征的病因及发病机制提供参考.

Behcet＇s disease （BD） is a systemic vasculitis of unknown etiology.Uveitis,which is common and therapeutically challenging,is the major ocular manifestation of BD.Researches have shown that,in addition to the genetic components （e.g.HLA-B51）,environmental factors such as infection also play important roles in the pathogenesis of BD.In recent years,with the advances in bio-detecting technologies,accumulating evidence has shown an association between microbial infections and previously believed noninfectious immune disorders.Specifically,there has been increasing research interest in roles of infection in pathogenesis of BD.A variety of microbes,including streptococcus sanguis,staphylococcus aureus,intestinal flora,herpes simplcx virus and etc.,have been suggested to be involved.The objective of this article is to review current research progress concerning BD and infection,as well as to provide some recommendations for future investigations into this subject.