1GINN S L,ALEXANDER I E,EDELSTEIN M L,et al.Gene therapy clinical trials worldwide to 2012:an update[J].J Gene Med,2013,15(2):65-77.
2JIN L,ZENG X,LIU M,et al.Current progress in gene delivery technology based on chemical methods and nano-carriers[J].Theranostics,2014,4(3):240-255.
3THOMAS C E,EHRHARDT A,KAY M A.Progress and problems with the use of viral vectors for gene therapy[J].Nat Rev Genet,2003,4(5):346-358.
4SHCHARBIN D,SHAKHBAZAU A,BRYSZEWSKA M.Poly(amidoamine)dendrimer complexes as a platform for gene delivery[J].Exp Opin Drug Deliv,2013,10(12):1687-1698.
5ASSESSMENT OF ADENOVIRAL VECTOR SAFETY ANG TOXICITY.Report of the national institutes of health recombinant DNA advisory committee[J].Hum Gene Ther,2002,13(1):3-13.
6MORRAL N,O'NEAL W K,RICE K,et al.Lethal toxicity,severe endothelial injury,and a threshold effect with high doses of an adenoviral vector in baboons[J].Hum Gene Ther,2002,13(1):143-154.
7THOMAS C E,EHRHARDT A,KAY M A.Progress and problems with the use of viral vectors for gene therapy[J].Nat Rev Genet,2003,4(5):346-358.
8YIN H,KANASTY R L,ELTOUKHY A A,et al.Non-viral vectors for gene-based therapy[J].Nat Rev Genet,2014,15(8):541-555.
10WANG T,UPPONI J R,TORCHILIN V P.Design of multifunctional non-viral gene vectors to overcome physiological barriers:dilemmas and strategies[J].Int J Pharm,2012,427(1):3-20.
4COLLINS S A,GUINN B A,HARRISON P T. et al. Viral vectors in cancer immunotherapy: which vector for which strategy [J]. Curr Gene Ther,2008,8(2):66-78.
5KAWAKAMI S, HIGUCHI Y, HASHIDA M. Nonviral approaches for targeted delivery of plasmid DNA and oligonucleotide [J]. J Pharm Sci, 2008,97 : 726-745.
6LI S D,HUANG L. Non viral is superior to viral gene delivery [J]. J Control Release, 2007,123 (3) :181-183.
8NEU M, FISCHER D, KISSEL T. Recent advances in rational gene transfer vector design based on poly ( ethylene imine ) and its derivatives [J]. J Gene Meal, 2005,7(8):992-1009.
9VAN DER WOUDEN E A, SANDOVICI M, HENNING R H,et al. Approaches and methods in gene therapy for kidney disease [J]. J Pharmacol Toxicol Methods, 2004,50 ( 1 ) : 13-24.
10NISHIKAWA M, TAKAKURA Y, HASHIDA M. Theoretical considerations involving the pharmacokinetics of plasmid DNA [J ]. Adv Drug Deliver Rev,2005,57(5):675-688.
