多西他赛与奈达铂联合治疗晚期非小细胞肺癌的疗效观察

Dovetail combined with Palatine clinical efficacy in patients with advanced non-small cell lung cancer

目的探讨多西他赛与奈达铂联合治疗晚期非小细胞肺癌的临床疗效。方法以2009年4月至2011年1月陕西省肿瘤医院收治的78例晚期非小细胞肺癌患者为研究对象,按照随机数字表法分为两组,分别进行多西他赛+奈达铂化疗(观察组)和多西他赛+顺铂化疗(对照组)。比较两组患者的近、远期疗效和不良反应。结果观察组总有效率为41.0%,对照组总有效率为43.6%,差异无统计学意义(P>0.05)。观察组患者的1年、3年生存率分别为35.9%和12.8%,平均生存时间、无进展生存时间分别为(9.31±2.96)个月和(4.19±2.05)个月。对照组患者的1年、3年生存率分别为33.3%、10.3%,平均生存时间、无进展生存时间分别为(9.43±3.15)个月和(3.96±2.14)个月,差异均无统计学意义(均P>0.05)。观察组恶心呕吐6例(15.4%),食欲不振9例(23.1%),消化道反应8例(20.5%),肾毒性2例(5.1%),肝毒性1例(2.6%)。对照组恶心呕吐14例(35.9%),食欲不振19例(48.7%),消化道反应17例(43.6%),肾毒性9例(23.1%),肝毒性5例(12.8%),差异有统计学意义(P<0.05)。结论多西他赛联合奈达铂治疗晚期非小细胞肺癌疗效确切,能够明显降低不良反应,安全可靠。

Objective To investigate dovetail combined with Palatine clinical efficacy in patients with advanced non-small cell lung cancer. Methods The 78 patients with advanced non-small cell lung cancer in April 2009 to January 2011 in our hospital for the study,according to the random number table randomly divided into two groups,respectively dovetail ＋ Palatine chemotherapy（ treatment group） and dovetail ＋ splatting（ control group）. Comparison of two recent,long-term efficacy and adverse reactions.Results The total effective rate was 41. 0% in the control group,the total effective rate was 43. 6%,the difference was not statistically significant（ P〈0. 05）. Treated for 1 year,3 year survival rates were35. 9%,12. 8%,with an average survival time of progression-free survival time was（ 9. 31 ± 2. 96）months,（ 4. 19 ± 2. 05） months; group 1 year,3 years survival rates were 33. 3%,10. 3%,with an average survival time of progression-free survival time was（ 9. 43 ± 3. 15） months,（ 3. 96 ± 2. 14） months,these differences are not statistically significant（ P〉0. 05）. Treated nausea,vomiting 6 cases（ 15. 4%）,loss of appetite nine cases（ 23. 1%）,gastrointestinal reactions 8 cases（ 20. 5%）,renal toxicity in 2 cases（ 5. 1%）,one case of liver toxicity（ 2. 6%）; treatment nausea,vomiting,14 cases（ 35. 9%）,anorexia19 cases（ 48. 7%）,gastrointestinal reactions 17 cases（ 43. 6%）,renal toxicity nine cases（ 23. 1%）,toxicity 5 cases（ 12. 8%）,the difference was statistically significance（ P〈0. 05） Conclusion Dovetail combined palatine treatment of advanced non-small cell lung cancer efficacy,can significantly reduce adverse reactions,safe and reliable.