IκB激酶β在乳腺癌组织中的表达及意义

Expression of IκB kinase β in breast cancer tissues and its significance

目的：检测IκB激酶β（IKKβ）在乳腺癌和正常乳腺组织中的表达并探讨其临床意义。方法收集2004年1月至2014年12月就诊于中南大学湘雅三医院的乳腺癌患者80例的手术标本，以同期10例正常乳腺组织手术标本作为对照，应用免疫组化法检测乳腺癌组织和正常乳腺组织中IKKβ的表达，分析其与乳腺癌临床病理参数的关系。结果乳腺癌和正常乳腺组织中IKKβ表达阳性率分别为62.5%（50/80）和10.0%（1/10），组间比较差异有统计学意义（P＜0.05）。IKKβ表达与乳腺癌T分期及淋巴结转移有关（均P＜0.05），与患者年龄、肿瘤组织学类型、病理分级及远处转移无关（均P＜0.05）。结论 KKβ表达与乳腺癌的发生发展有关，可能在乳腺癌的发生发展中发挥重要作用。

Objective To determine the expression of IκB kinase β（IKKβ）in breast cancer and normal breast tissues,and to investigate its clinical significance. Methods The surgical specimens of 80 patients with breast cancer,who were hospitalized in the Third Xiangya Hospital of Central South University between January 2004 and December 2014,were included as the subjects in the study. Ten normal breast tissues from a contemporary cohort were included as the control. The expression of IKKβin the breast cancer and normal breast tissues was determined by immunohistochemistry（IHC）,respectively,and its correlation with the clinicopathological parameters of breast cancer was analyzed. Results The positive expression of IKKβin the breast cancer and normal breast tissues was 62.5%（50/80）and 10.0%（1/10）,respectively,and there was statistically significant difference between the two groups （P〈0.05）. The expression of IKKβ was correlated with the T stage of breast cancer and the lymph node metasis （both P〈0.05）,and was not correlated with the age,tumor histological type,pathological grade and distant metastasis （all P＆gt;0.05）. Conclusion IKKβ expression is correlated with the occurrence and development of breast cancer,which may play an important role in the occurrence and development of breast cancer.