老年高血压、糖尿病、颈动脉粥样硬化性狭窄患者认知功能障碍研究

Correlation analysis of hypertension,diabetes mellitus,carotid atherosclerotic stenosis with cognitive dysfunction in elderly patients

目的探讨老年患者常见慢性疾病高血压、糖尿病、颈动脉粥样硬化性狭窄与认知功能障碍的关系。方法受试者均接受血压、血糖、颈动脉彩色多普勒超声检测,采用简易精神状态检查表(mini-mental state examination,MMSE)和蒙特利尔认知评估(Montreal cognitive assessment,Mo CA)评估认知功能,比较分析不同疾病严重程度患者的认知功能。结果患有高血压、糖尿病、颈动脉粥样硬化性狭窄中任一种老年慢性疾病的认知功能水平较正常对照组均显著降低,且认知功能障碍程度与疾病严重程度呈正相关(P<0.05)。结论高血压、糖尿病、颈动脉粥样硬化性狭窄与认知功能障碍显著相关,且血压越高、血糖越高、颈动脉管腔越狭窄,患者的认知功能受损越严重。

Objective To investigate the relationship between hypertension, diabetes mellitus, carotid atherosclerotic stenosis and cognitive dysfunction in elderly patients. Methods All subjects received the detection of blood pressure, blood glucose and carotid artery color Doppler ultrasound. Cognitive function was assessed by using mini- mental state examination （MMSE） and Montreal cognitive assessment （MoCA）. Results The cognitive function of the elderly patients with hypertension, diabetes and carotid atherosclerosis was significantly lower than that of normal control group, and the level of cognitive dysfunction was positively correlated to the severity of disease （P〈0. 05）. Conclusions Hypertension, diabetes mellitus, carotid atherosclerotic stenosis are significantly associated with the degree of cognitive dysfunction, and the higher blood pressure, blood glucose and carotid stenosis, the more serious cognitive impairment.