探讨X染色体结构与数目异常对激素水平及个体发育的影响

Investigate the structure and the number of X chromosome abnormalities affect hormone levels and ontogeny

目的探讨X染色体结构与数目异常对性激素水平和个体发育的影响。方法通过外周血染色体核型分析,找出X染色体结构畸变、数目异常的个体,对他们进行激素水平的检测,然后再检查他们的身高、性腺发育、脏器发育、智力发育的水平,综合分析染色体核型、激素水平、个体发育水平的关系。结果我们找到45,X个体11人,47,XXX个体2人,47,XXY个体8人,嵌合体3人,X染色体结构异常5人,包括(易位3人,等臂2人),共29人,对他们的激素水平分别给与检测,生长发育进行了评估。结论这29人激素水平的变化,个体发育的变化,是由于X染色体结构与数目异常导致的。

Objective： Investigate the structure and the number of X chromosomes and individual levels of sex hormones torso, abnormal organ development impact. Methods： By peripheral blood karyotype analysis to identify the X chromosome structural aberrations, an abnormal number of individuals, on their hormone level of detection, and then check their height, gonadal development, organ development, the level of intellectual development, a comprehensive analysis of chromosomal relationship karyotype, hormone levels, levels of ontogeny. Results： We found 45,X individuals 11, 47,XXX individuals 2, 47,XXY individuals eight people, three people chimera, X chromosome structural abnormalities of five people, including （translocation three people, and so the ann 2） , a total of 29 people, on their hormone levels were given detection, growth was assessed. Conclusion： Changes in hormone levels which 29 people, ontogenetic variation is due to the structure and the number of X chromosome abnormalities caused.