苏州地区血清维生素D水平与早产的相关性研究

Serum vitamin D levels and premature birth in suzhou correlation studies

目的分析苏州地区早产孕妇与足月妊娠孕妇早孕期血清25羟维生素D[25-hydroxy vitamin D,25(OH)D]水平差异,为妊娠期补充维生素D,及是否可成为针对早产的潜在预防策略作前期研究工作。方法选择2013年1月份在南京医科大学附属苏州医院产科门诊进行产前保健的孕妇,分为足月妊娠组及早产组,取妊娠13-16w孕妇血清,排除慢性肝病、甲状腺功能亢进和结缔组织疾病者。采用酶联免疫吸附法测定血清25(OH)D水平,在终止妊娠时采取生殖道分泌物行细菌培养,采用t检验比较足月妊娠组及早产组25(OH)D水平及生殖道感染率。结果早产组25(OH)D(12.02±8.59)nmol/L,明显低于足月妊娠组(27.46±3.61)nmol/L;早产组生殖道感染率(57%)明显高于足月妊娠组(21%),两组比较差异有显著性意义。结论苏州地区孕妇维生素D水平普遍不足,早产组较对照组维生素D水平更低,孕妇应该根据自身情况额外补充维生素D制剂。

Objective： Analysis of preterm pregnant women in suzhou and full-term pregnancy pregnant women early in pregnancy serum 25 OH vitamin D [25 a hydroxy vitamin D, 25 （OH） D] level differences, for vitamin D supplements during pregnancy, and can be potentially against premature prevention strategies for preliminary research work. Methods： From January 2013 in suzhou hospital affiliated to nanjing medical university obstetrics outpatient antenatal care of pregnant women, divided into the full-term pregnancy, preterm group, from 13 to 16 weeks pregnant women serum, eliminate chronic liver disease, thyroid function hyperfunction and connective tissue diseases. Enzyme-linked immunosorbent method is used to determine the serum 25 （OH） D level, at the time of termination to genital tract secretions bacterial culture, using t test to compare full- term pregnancy, preterm group of 25 （OH） D levels and genital tract infection. Results： The preterm group of 25 （OH） D （12.02 ± 8.59） nmol/L, significantly lower than the full term pregnancy group （27.46 ± 3.61） nmol/L; Reproductive tract infection （57%） were preterm group was obviously higher than that of full term pregnancy group （21%） , significant difference comparing the two groups. Conclusion： The insufficiency of pregnant women vitamin D levels in suzhou, the preterm group than control group in lower vitamin D levels, pregnant women should according to oneself circumstance for additional vitamin D preparation.