摘要
患者,女,27岁。咳嗽4个月,躯干、四肢红斑、水疱及脱发2个月。皮肤科情况:头顶发稀疏,面部充血性红斑,双手指腹红斑,躯干四肢可见大小不等水疱、血疱,疱壁紧张,尼氏征阴性。外周血红细胞和血红蛋白下降、补体下降,ANA、抗ds-DNA阳性,血清抗VII胶原抗体阳性。患者疱液免疫检测:ANA、抗ds-DNA、抗SSA、抗SSB、抗组蛋白抗体(+),抗RO 52抗体(+++),抗核小体抗体(++),滴度与血液中滴度平行。诊断为大疱性系统性红斑狼疮。
A 27-years-old female patient presented with cough for 4 months and erythema, vesicle and hair-loss for 2 months. Physical examination revealed sparse hair on the scalp, erythema on the face and finger pulp, bullas on the trunk and extremities. The bullas were negative in Nikolskys sign. Red blood cells and hemoglobin declined and anti-nuclear antibody, anti-ds DNA, antibody to type VII collagen in peripheral blood were positive. ANA, anti-dsDNA, anti-SSA, anti-SSB, anti-histone, anti-Ro 52 and anti-nucleosome antibodies in blister fluids were positive. The diagnosis of bullous systemic lupus erythematosus was made.
出处
《中国麻风皮肤病杂志》
2016年第8期468-470,共3页
China Journal of Leprosy and Skin Diseases
基金
国家自然科学基金(编号:81071301
81371731
81301370)
关键词
系统性红斑狼疮
大疱性
疱液
systemic lupus erythematosus
bullous
blister fluids
