慢性心力衰竭并心房颤动患者与血清胱抑素C及B型钠尿肽的相关性分析

Correlation analysis of chronic heart failure combined with atrial fibrillation patients with the serum level of serum cystatin C and B type natriuretic peptide

目的探讨慢性心力衰竭（CHF）并房颤患者与血清胱抑素C（Cys-C）、脑钠肽（BNP）的相关性,评价其对慢性心力衰竭并房颤患者早期的预测价值。方法选取2015年7月至2015年11月CHF患者126例,其中心房颤动患者46例,非心房颤动患者80例,比较两组患者Cys-C及BNP间是否存在差异,Cys-c、BNP对慢性心力衰竭并心房颤动患者早期是否具有预测价值。结果 CHF合并心房颤动患者Cys-C、BNP水平高于CHF未合并心房颤动患者,差异有统计学意义（P〈0.05）;Cys-C对慢性心力衰竭并心房颤动患者的受试者工作特征曲线（ROC曲线）下面积为0.794（95%CI0.708～0.881,P〈0.05）;BNP对慢性心力衰竭并心房颤动患者的ROC曲线下面积为0.716（95%CI 0.617～0.814,P〈0.05）。结论慢性心力衰竭并心房颤动患者Cys-C、BNP水平高于慢性心力衰竭未合并心房颤动患者,且Cys-C、BNP对慢性心力衰竭并心房颤动患者早期有预测价值。

Objective To investigate the correlation of chronic heart failure（ CHF） combined with atrial fibrillation patients with the serum level of cystatin C（ Cys-C） and brain natriuretic peptide（ BNP）,and to evaluate the predictive value of Cys-C and BNP in the early stage of patients with chronic heart failure combined with atrial fibrillation. Methods One hundred and twentysix CHF patients were selected from July 2015 to November 2015,including 46 patients with atrial fibrillation（ AF） and 80 patients without AF. The differences of Cys-C and BNP between the two groups were compared,and whether it has early predictive value in patients with CHF combined with AF. Results The levels of Cys-C and BNP of CHF combined with AF group were higher than those of CHF without AF group,the differences were significant（ P〈0. 05）. The ROC curve area was 0. 794（ 95%CI 0. 708-0. 881,P〈0. 05） by Cys-C on the CHF combined with AF patients,the ROC curve area was 0. 716（ 95% CI 0. 617-0. 814,P〈0. 05） by BNP on the CHF combined with AF patients. Conclusion The levels of Cys-C and BNP of patients with CHF combined with AF are higher than those of CHF without AF patients. Cys-C and BNP has the predictive value for patients with chronic heart failure combined with atrial fibrillation at early stage.