炎症因子调节细胞自噬的研究进展

Research progress on inflammatory cytokines in the regulation of autophagy

自噬是细胞维持内环境稳态的一种重要的自我保护机制,是依赖于溶酶体降解胞内受损的蛋白质和细胞器的过程。炎症是机体受到损伤或者病原体侵入时激活免疫系统以分泌多种细胞因子的一种保护性反应。异常的炎症反应能够扰乱细胞内环境的稳定,而自噬有助于抑制炎症反应以维持内环境的稳态。自噬在炎症反应中却是一把双刃剑,自噬既可以维持机体内环境稳定而起保护作用,过度的自噬也可能会损伤细胞。基于炎症与自噬之间的密切关系,本文介绍了3类炎症相关因子:先天免疫模式识别受体、细胞因子、炎症相关转录因子对细胞内自噬水平的调节作用,为深入研究自噬和炎症相互关系的作用机制提供参考。

Autophagy is a kind of self-protective mechanism that cells keep internal homeostasis, and alysosome-depended process to degrade damaged proteins and organelles. Inflammation is a protective reaction whenorganism is hurt or invaded by pathogen and the immune system is activated and various cell factors are secreted.Autophagy is a rapier in inflammatory reaction, which not only has protective function by keeping homeostasis, butalso worsens the state of an illness. Based on the tight connection between inflammation and autophagy, three kindsof inflammation-related factors will discussed in this review, including innate immune receptors, cytokines andinflammation-related transcription factors, which can regulate the level of autophagy in cells. Our article willprovide some references about relationship between autophagy and inflammation for further research.