对乙酰氨基酚暴露因素对儿童喘息性疾病伴发热疗效的影响被引量：3

下载PDF

导出

摘要目的观察对乙酰氨基酚暴露因素对儿童喘息性疾病伴发热疗效的影响。方法选取2014年12月至2015年12月佛山市南海区第五人民医院收治的342例喘息性疾病伴发热患儿,按照数字随机法分为试验组(对乙酰氨基酚组)及对照组(布洛芬组),试验组及对照组又按药物剂量分为高剂量组、低剂量组两小组,试验组使用对乙酰氨基酚混悬液为退热药物,对照组使用布洛芬混悬液为退热药物,比较不同组住院时间,喘息症状评分,皮质激素使用率(静脉或口服)。结果对乙酰氨基酚组平均住院天数长于布洛芬组(P<0.05),且对乙酰氨基酚低剂量组平均住院天数长于高剂量组(P<0.05)。治疗后,高、低剂量对乙酰氨基酚组症状评分均高于布洛芬组(P<0.05)。对乙酰氨基酚组皮质激素使用率高于布洛芬组(P<0.05)。结论对乙酰氨基酚暴露因素能增加儿童喘息性疾病伴发热的严重程度,影响治疗效果。临床上选择退热药物时,需注意对乙酰氨基酚的不良影响。

作者卢鋆锋古刘王曹楚琼孔宪滔

机构地区佛山市南海区第五人民医院儿科

出处《河南医学研究》 CAS 2016年第9期1569-1571,共3页 Henan Medical Research

关键词对乙酰氨基酚暴露因素儿童喘息性疾病发热

分类号 R725.6 [医药卫生—儿科]

引文网络
相关文献

参考文献10

1Varner A E, Busse W W, Lemanske R F Jr. Hypothesis: decreased use of pediatric aspirin has contributed to the increasing prevalence of childhood asthma [ J ]. Ann Allergy Asthma I mmunol, 1998,81 ( 4 ) : 347 - 351.
2Shaheen S O,Sterne J A,Songhurst C E,Bttrney P G. Frequent parac- etamol use and asthma in adtdts [ J ]. Thorax, 2000,55 ( 4 ) : 266 - 270.
3Garcla - Mareos L, Sanchez - Solis M, Perez - Fernandez V. Early ex- posure to acetaminophen and allergic disorders[ J]. Curt Opin Allergy Clin Immuno1,2011,11 (3) : 162 - 173.
4Newson R B, Shaheen S O, Chinn S, et al. Paracetamol sales and atop- ic disease in children and adults: an ecological analysis [ J ]. Eur Re-spir J,2000,16(5) :817 -823.
5Beasley R,Clayton T,Crane J,et al. ISAAC Phase Three Study Group. Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjuncfivifis, and eczema in children aged 6 -7 years: analysis from Phase Three of the ISAAC programme[J]. Lancet 2008,372(9643) :1039 - 1048.
6Beasley R W, Clayton T O, Crane J, et al. ISAAC Phase Three Study Group. Aeetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: International Study of Asthma and Aller- gies in Childhood Phase Three[ JJ. Am J Respir Crit Care Med ,2011, 183(2) :171 - 178.
7Dimova S, Hoet P H, Dinsdale D, et al. Acetaminophen decreases iu- tracellular glutathione levels and modulates cytokine production in hu- man alveolar maerophages and type II pneumocytes in vitro~ J 1. Irtt J Biochem Cell Biol,2005,37(8) :1727 -1737.
8Farquhar H, Stewart A, Mitchell E, et al. The role of paracetamol in the pathogenesis of asthma [ J~. Clin Exp Allergy, 2010, 40 ( 1 ) : 32 -41.
9Barnes P J. Reactive oxygen species and airway inflammation[ J]. Free Radic Biol Med, 1990,9 (3) :235 - 243.
10Peterson J D,Herzenberg L A,Vasquez K,et al. Glutathione levels in anti- gen- presenting cells modulate Thl versus Th2 response patterns [ J ]. Proe Natl Acad Sei USA, 1998,95 (6) :3071 -3076.