儿童急性下呼吸道肺炎克雷伯菌感染特点及其细菌耐药性分析

Analysis of characteristics and bacterial drug resistance of Klebsiella pneumonia infection in acute lower respiratory of children

目的分析儿童急性下呼吸道肺炎克雷伯菌感染特点及其细菌耐药性。方法随机选取2013年12月-2015年9月本院收治的儿童急性下呼吸道肺炎600例,培养痰液并检测克雷伯菌感染情况。结果克雷伯菌感染患者检出148例,检出率为24.67%,下呼吸道肺炎克雷伯菌感染对氨苄西林、头孢唑林、磺胺甲恶唑/甲氧苄啶、呋喃妥因、氨苄西林/舒巴坦、头孢曲松、庆大霉素的耐药性较高,耐药率分别为100.00%、63.51%、60.81%、80.41%、58.78%、47.97%、34.46%。对左氧氟沙星、哌拉西林/他唑巴坦、头孢替坦、阿米卡星、亚胺培南、厄他培南的耐药性相对较差,耐药率分别为4.83%、2.70%、4.05%、0.68%、1.35%、1.35%。结论克雷伯菌是下呼吸道肺炎感染的常见病菌,患者治疗的过程中需要合理的选择抗菌药物。

Objective To analyze the characteristics and bacterial resistance of Klebsiella pneumonia infection in acute lower respiratory infection of children. Methods We randomly selected 600 cases of children with acute lower respiratory pneumonia from our hospital during December 2013- September 2015,cultivated the sputum and detected the infection condition of Klebsiella bacteria. Results Among all the detected 600 cases,148 ones were infected by Klebsiella bacteria（ 24. 67%）. The bacterial drug resistance of Klebsiella pneumonia to ampicillin,cefazolin,sulfamethoxazole / trimethoprim,nitrofurantoin,ampicillin / sulbactam,ceftriaxone,and gentamycin were comparatively high,with the resistance of 100. 00%,63. 51%,60. 81%,80. 41%,58. 78%,47. 97% and 34. 46%. On the contrary,the bacterial drug resistance of Klebsiella pneumonia to levofloxacin,piperacillin / tazobactam,cefotetan,amikacin and imipenem were relatively lower,with the resistance of 4. 83%,2. 70%,4. 05%,0. 68%,1. 35% and 1. 35%. Conclusion Klebsiella pneumonia infection in acute lower respiratory infection is common. Rational application of antibiotics in clinics should be made during treatment.