摘要
A simple and efficient one-pot procedure has been developed for the construction of pyrrolo[ 1,2-a]pyrimidines via the three-component domino reaction of 5-aminopyrazoles, acetylenedicarboxylates and malononitrile under catalyst-free, microwave irradiation conditions. The key step in this transformation is the N--N bond cleavage reac- tion of the 5-aminopyrazole substrate, which has been reported in this context for the first time in this study. The advantages of this protocol include readily available starting materials, short reaction times and good regioselectivity.
A simple and efficient one-pot procedure has been developed for the construction of pyrrolo[ 1,2-a]pyrimidines via the three-component domino reaction of 5-aminopyrazoles, acetylenedicarboxylates and malononitrile under catalyst-free, microwave irradiation conditions. The key step in this transformation is the N--N bond cleavage reac- tion of the 5-aminopyrazole substrate, which has been reported in this context for the first time in this study. The advantages of this protocol include readily available starting materials, short reaction times and good regioselectivity.
基金
the Major Basic Research Project of the Natural Science Founda- tion of the Jiangsu Higher Education Institutions （No. 15KJA150006）, the Natural Science Foundation of Jiangsu Province （No. BK20131160）, a project fund from the Priority Academic Project Development of the Jiangsu Higher Education Institutions, the Foundation of the Key Laboratory of Organic Synthesis of Jiangsu Province （No. JSK1210） and the Jiangsu College Grad- uate Research and Innovation Project of the Jiangsu Province Department of Education （No. KYZZ 0336）.
