Q开关Nd:YAG激光联合化瘀祛斑胶囊治疗黄褐斑疗效观察

Effective Observation of Q-switch Nd:YAG Laser Combined with Huayu Quban Capsule in Treating Melasma

目的观察Q开关Nd:YAG激光联合化瘀祛斑胶囊治疗黄褐斑的疗效。方法将90例黄褐斑患者随机分为2组,每组45例,治疗组予Q开关Nd:YAG激光联合化瘀祛斑胶囊治疗,对照组仅予单纯Q开关Nd:YAG激光治疗。Q开关Nd:YAG激光治疗每周1次,治疗8周后改为每2周1次治疗8周,疗程共16周。化瘀祛斑胶囊2次/d,5粒/次,连服16周。于治疗第8周、第16周评判疗效,随访12周观察复发率。结果 16周时治疗组有效率为84.4%,对照组为68.9%,差异有统计学意义(P<0.05);治疗组复发率为17.8%,对照组复发率为37.8%,差异有统计学意义(P<0.05)。结论 Q开关Nd-YAG激光联合化瘀祛斑胶囊较单纯应用激光治疗更有效,复发率低,值得临床推广。

Objective In order to explore the efficacy of Q-switch Nd： YAG laser combining with Huayu Quban capsute in treating melasma. Methods Ninety patients with melasma were divided into the treatment group and the control group. Forty- five patients in treatment group were treated once a week for 8 weeks and then once biweekly for 8 weeks by Q-switch Nd： YAG laser combing with Huayu Quban capsule five capsules one time and two times a day for 16 weeks. Forty-five patients of control group were only treated by the Q-switch Nd： YAG laser. The curative effect was judged after treatment in 8th, 16th weeks. Results The effective rate of treatment group in 16th week was 84.4% and that of control group was 68.9%. The two groups had statistical significance （P〈0.05）. The relapse rate was 17.8% and 37.8% for treatment group and control group, respectively. The two groups had statistical significance （P〈0.05）. Conclusion The Q-switch Nd： YAG laser combining with Huayu Quban capsule is more effective and with a lower relapse rate in treatment of melasma than the Q-switch Nd： YAG laser. It is suitable for clinical application.