胃癌患者血清胃蛋白酶原含量的检测临床分析

Clinical Analysis of Detection of Serum Pepsinogen Levels in Patients With Gastric Cancer

目的探讨血清PGⅡ、PGⅠ的含量与胃癌的关系,为早期胃癌的诊断提供线索参考。方法用放射免疫分型的方法分别检测正常人、胃癌患者、胃溃疡患者、十二指肠溃疡患者、慢性萎缩性胃炎患者的PGⅠ和PGⅡ的含量,比较差异。结果和正常人相比,胃溃疡患者的PGⅠ稍微升高,而PGⅡ明显升高;十二指肠溃疡患者的PGⅠ明显升高;慢性萎缩性胃炎患者的PGⅠ水平下降;胃癌患者的PGⅠ显著降低,PGⅡ变化不显著,但是PGⅠ/PGⅡ显著下降。结论对胃癌患者检测PGⅠ、PGⅡ含量的变化对胃癌的早期诊断具有非常重要的临床意义。

Objective To investigate the relationship between serum PG II, PG I and gastric cancer, and to provide clues for the diagnosis of early gastric cancer, provide clues for the diagnosis of early gastric cancer. Methods The content of PG I and PG II in normal persons, gastric cancer patients, patients with gastric ulcer, duodenal ulcer and chronic atrophicgastritis were detected by radioimmunoassay. Results Compared with normal subjects, PG I was slightly higher in patients with gastric ulcer, while PG II was significantly higher, PG I was significantly increased in patients with duodenal ulcer, PG I level in patients with chronic atrophic gastritis, PG I was significantly decreased in patients with gastric cancer, and the change of PG II was not significant, but PG I / PG II was significantly decreased. Conclusion The changes of PG I and PG II in gastric cancer patients have very important clinical significance in the early diagnosis of gastric cancer.