手术去势联合间歇性雄激素全阻断疗法治疗局部进展期前列腺癌的临床疗效

Clinical Efficacy of Surgical Castration Combined With Intermittent Androgen Blockade Therapy in the Treatment of Locally Advanced Prostate Cancer

目的探讨手术去势联合间歇性雄激素全阻断疗法治疗局部进展期前列腺癌的临床疗效。方法选取我院收治的局部进展期前列腺癌患者50例,将其随机分为对照组(27例)和观察组(23例),对照组患者给予手术去势治疗,观察组患者给予手术去势联合间歇性雄激素全阻断疗法治疗,分析比较前列腺特异性抗原水平(PSA)、生活质量指数(QOL)等各项指标变化情况。结果观察组的PFS_(time)、OS_(time)高于对照组,且与对照组相比,治疗后观察组的PSA和QOL值分别为(3.6±1.2)ng/L、(82.3±1.3)分,差异有统计学意义(P<0.05)。结论手术去势联合间歇性雄激素全阻断疗法治疗局部进展期前列腺癌的疗效明显更优。

Objective To investigate the clinical effect of surgical castration combined with intermittent androgen blockade therapy in the treatment of locally advanced prostate cancer. Methods 50 cases of locally advanced prostate cancer patients in our hospital, were randomly assigned for control group（27 cases） and observation group（n=23）, control group were treated with surgical castration, patients in observation group were given surgical castration with intermittent androgen blocking therapy, analysis and comparison of prostate specific antigen（PSA）, index of life quality（QOL） and other indexes. Results The observation group PFStime OStime higher than control group, and compared with the control group, after treatment, observation group of PSA and QOL respectively（3.6±1.2） ng/L,（82.3±1.3） value, and the difference is statistically significant（P〈0.05）. ConclusionThe curative effect of surgical castration combined with intermittent androgen blockade therapy in the treatment of locally advanced prostate cancer is significantly better.