摘要
目的观察小剂量环磷酰胺联合强的松治疗难治性多发性骨髓瘤的临床疗效。方法 64例难治性多发性骨髓瘤患者,分为2组,治疗组给予小剂量环磷酰胺联合强的松治疗,对照组给予沙利度胺联合强的松。疗程结束后评价临床疗效。结果治疗组与对照组的总有效率分别为90.63%(29/32),81.25%(26/32),两组比较差异有统计学意义(P<0.05);2不良反应比较差异有统计学意义(P<0.05)。结论小剂量环磷酰胺联合强的松方案治疗难治性多发性骨髓瘤的疗效好,不良反应较为轻微。
Objective To observate low-dose cyclophosphamide combined with prednisone in treatment of refractory multiple myeloma. Methods 64 cases ofrefractory multiple myeloma patients,divided into two groups,the treatment group received low-dose cyclophosphamide combined with prednisone therapy,the control group received thalidomide plus prednisone. Evaluation of clinical efficacy after treatment. Results Treatment group and control group the total effective rate of 90.63%,respectively（29/32）,81.25%（ 26/32）,the difference was significant（P〈0.05）. 2 adverse reaction was significantly different（P〈0.05）. Conclusion Low-dose cyclophosphamide combined with prednisone in the treatment of refractory multiple myeloma effect is significant,adverse reactions are relatively minor.
出处
《中国卫生标准管理》
2016年第14期112-113,共2页
China Health Standard Management
