肾癌相关长链非编码RNA研究进展

Research progress on long non-coding RNA in renal cell carcinoma

长链非编码RNA(long non-coding RNA,lncRNA)是一类由RNA聚合酶Ⅱ转录及可变剪接而来、长度大于200个核苷酸、无蛋白编码功能的RNA分子。众多研究表明其在表观遗传学、转录等水平发挥重要的调控作用,且其异常表达与肾癌(renal cell carcinoma,RCC)的发生、发展、转移和预后等明显相关。旨在总结RCC相关lnc RNA最新研究进展,浅析lnc RNA在RCC发生、发展中的潜在分子机制,为RCC的预防、早期诊治及预后评估提供一种新的理论依据。

Long non-coding RNA （lncRNA） is a class of RNA molecules, transcripted by RNA polymerase Ⅱ, which consists of more than 200 nucleotides and protein-coding function. Many studies have indicated that lncRNA plays an important role in epigenetics, transcription and post-translational processing. The abnormal expression of lncRNA significantly correlates with occurence, development, and metastasis of renal cell carcinoma （RCC） and prognosis of the patients with RCC. This paper summarizes the advances in the research on lncRNA in RCC to reveal the mechanisms of the disease at the molecular level, in order to provide new methods of prevention, diagnosis, treatment and prognostic assessment of RCC.