HCV NS5A抑制剂研究进展

Research progress of HCV NS5A complex inhibitors

近年来抑制丙型肝炎病毒(HCV)复制的直接抗病毒药物得到了快速的发展,HCV非结构蛋白5A(NS5A)抑制剂由于抗病毒活性强、清除病毒快速和抗病毒谱广的特点成为了HCV抑制剂研究的新热点。本文综述了2010年以来有关HCV NS5A抑制剂研究的主要进展,并从化学结构角度出发,对不同化合物的药学特点进行分别阐述和归纳总结。

Direct acting antivirals against the hepatitis C virus （HCV） have been developed and the field has been under a rapid progress in recent years. Especially, HCV inhibitors targeting nonstructural 5A （NS5A） protein are attracting much attention due to the potent antiviral activity, fast viral clearance and broad antiviral spectrum. This article is prepared to cover the main progress of HCV NS5A complex inhibitors in the market since 2010. The pharmaceutical characteristics of diverse compounds are described and summarized according to their different chemotypes.