摘要
目的研究纤溶酶原激活物抑制物-1(PAI-1)基因4G/5G位点多态性与脑梗死的关系。方法根据急性缺血性脑卒中Org10172治疗试验(TOAST)分型,收集大动脉粥样硬化型(LAA)脑梗死患者125例,小动脉闭塞型(SAO)脑梗死患者147例,以及同期体检中心体检者127例。比较脑梗死患者临床特征及PAI-1基因4G/5G位点多态性。结果与对照组相比,LAA组和SAO组脑梗死患者高血压患病率、吸烟及饮酒比例显著增高,高密度脂蛋白胆固醇(HDL-C)水平低(均<0.05)。LAA组,SAO组及对照组均出现了4G/4G、4G/5G、5G/5G 3种基因型,3组基因型的分布差异有统计学意义(<0.05)。结论高血压、吸烟、饮酒、HDL-C水平降低是温州地区脑梗死患者的重要危险因素。温州地区人群PAI-1基因4G/5G位点4G/5G基因型是脑梗死的危险因素。
Objective To investigate the relationship of plasminogen activator inhibitor-1 （PAI-1） gene 4G/5G pol-ymorphism and cerebral infarction. Methods Data was prospectively collected from consecutive ischemic stroke inpa-tients in neurology department of Wenzhou central hospital. According to the TOAST criteria, 125 large-artery athero-sclerosis （LAA） patients and 147 Small-artery occlusion （SAO） patients were enrolled. The control group had 1 27 sub- jects from the Medical Examination Center in the same period. The clinical characteristics and 4G/5G polymorphism of PAI-1 gene were compared among the three groups. Result As compared with the controls, percentage of high blood pressure （HBP）, smoking, drinking, high-density lipoprotein cholesterol concentrations （HDL-C） in LAA and SAO gro-ups （allP 〈 0.05）. There were three genotypes （4G/4G、4G/5G、5G/5G） in each groups. There was significantly differ-ence of genotype frequency in the three groups （P 〈 0.05）. Conclusion HBP, smoking, drinking, decreasing high-den-sity lipoprotein cholesterol are risk factors of cerebral infarction population in Whenzhou district. The PAI-1 Gene 4G/5G genotype increases the risk of cerebral infarction.
出处
《现代实用医学》
2016年第8期988-989,1008,共3页
Modern Practical Medicine
基金
浙江省医药卫生科技计划(2011KYA148)
