正常儿童脑白质发育的DTI研究

DTI study on the cerebral white matter development of healthy children

目的：用DTI研究正常儿童脑白质发育特点。方法：收集50例1～12岁健康儿童脑DTI图像，分析第1组（1～3岁）、第2组（4～6岁）、第3组（7～9岁）及第4组（10～12岁）4个年龄组与脑白质内囊前肢、内囊后肢、胼胝体膝部、胼胝体压部及尾状核头部5个部位的各向异性指数（FA）值、ADC值的相关性及差异性。结果：内囊前肢、内囊后肢、胼胝体膝部及胼胝体压部的FA值与年龄呈正相关，尾状核头部的FA值与年龄呈负相关；内囊前肢、内囊后肢、胼胝体膝部、胼胝体压部及尾状核头部的ADC值均与年龄呈负相关。第1、2组间及第2、3组间内囊前肢、内囊后肢、胼胝体膝部及胼胝体压部的FA值、ADC值差异均有统计学意义（均P〈0.05）；第3、4组组间胼胝体膝部及胼胝体压部的FA值、ADC值差异均有统计学意义（均P〈0.05）。结论：DTI的FA值和ADC值能反映脑白质发育差异。

Objective：To investigate the difference of the different cerebral white matter and elucidate changes of the cerebral white matter in normal children. Methods：Collection the DTI images of the cerebral white matter of 50 healthy children,age range from 1 to 12 years,divided into 4 groups （group 1：1-3y,group 2：4-6y,group 3：7-9y and group 4：10-12y）. Analysis the correlation of the age and the FA values and ADC values of the 5 regions：anterior limb of the internal capsule （ALIC）,poste-rior limb of the internal capsule（PLIC）、genu of corpus callosum（GCC）、splenium of corpus callosum（SCC） and head of caudate nucleus （HCN） of the cerebral white matter. Analyze the difference of the FA values and ADC values of 4 age groups. Re-sults：The FA values increased with increasing age in ALIC、PLIC,GCC,SCC,while decreased with increasing age in HCN. The ADC values increased with increasing age in ALIC,PLIC,GCC,SCC and HCN. There were difference in ALIC,PLIC,SCC and GCC in FA and ADC values between group 1 and 2,group 2 and 3 .There were significant difference in FA and ADC values between group 3 and 4 in SCC and GCC. Conclusion：DTI can be used to analyze the difference of cerebral white matter of healthy children.