卵巢伴微浸润的浆液性交界性肿瘤临床病理学特征分析

Clinicopathologic study of serous borderline tumour with microinvasion in ovary

目的 探讨卵巢伴微浸润的浆液性交界性肿瘤（SBTM）临床病理特征。方法回顾性分析明确诊断的10例卵巢SBTM患者临床资料，观察卵巢SBTM的病理形态特点及免疫表型。结果患者年龄范围22～68岁；10例卵巢SBTM的上皮细胞均呈轻中度非典型增生，其中8例形成乳头结构，2例可见微乳头结构，肿瘤间质内均出现单个细胞或多个细胞组成的细胞簇，细胞质呈嗜酸性，10例卵巢SBTM肿瘤细胞均CK7和CAM5.2弥漫阳性，CA125和WT1部分肿瘤细胞阳性。结论 卵巢SBTM是一种具有低度恶性潜能的肿瘤，微浸润病变较小时，诊断时容易漏诊；由于有复发可能，建议密切随访。

Objective To explore the clinicopathological features of serous borderline tumour with microinvasion（SBTM） in ovary.MethodsThe clinical and pathologic findings of 10 patients with SBTM were evaluated.Hematoxylin and eosinstain,immunohistochemistry and histochemistry were performed on the archival paraffin sections.ResultsAmong the 10 patients,their age at the time of operation ranged from 22 to 68 years old.The epithelial cells showed mild to moderate atypical hyperplasia,and papillary（8 cases） or micropapillary（2 cases） formation.Individual cells or more cell clusters appeared in tumor stroma,and cytoplasm was eosinophilic.The tumor cells of 10 cases were all diffusely positive for CK7 and CAM5.2 with locally positive for CA125 and WT1.Conclusions SBTM is a kind of low-grade malignant tumor,which is easy to be missed when the micro-invasive lesions is small.Due to possible recurrence,long-term follow-up is recommended.