结肠炎相关的结直肠癌的癌变因素及信号转导机制研究进展

Research progress:malignant factors and pathogenesis associated signaling pathways of colitis-related colorectal cancer

炎症性肠病(IBD)是一种病因未明的结直肠炎性病变,随着病程延长,癌变风险增加。结肠炎相关性结直肠癌(CRC)是IBD最为严重的并发症,近年来全球CRC的发病率呈逐年上升趋势。本文讨论了CRC的主要癌变因素,包括IBD患者的病程、病变范围、遗传因素、生活方式及饮食习惯等,并对与CRC发病机制有关的信号转导通路如核因子κB(NF-κB)通路、Wnt通路、丝裂原活化蛋白激酶(MAPK)通路、白细胞介素6(IL-6)/转录激活子3(STAT3)通路和表皮生长因子(EGF)/表皮生长因子受体(EGFR)通路的激活,以及促炎因子和抑炎因子的表达失调进行了概述,为CRC的预防提供参考。

Inflammatory bowel disease （IBD） is a colorectal inflammatory disorder of unknown eti- ology. With the extension of the course of disease, IBD is associated with increased risk of colorectal cancer. Colitis-related colorectal cancer （CRC） is the most serious complication of IBD, and its global incidence has continued to rise in recent years. This paper not noly discusses the main malignant factors including the disease course, scope of lesions, genetic factors, lifestyle, and eating habits, but also outlines the CRC pathogenesis related signaling pathways, such as NF-KB pathway, Wnt path- way, mitogen-activated protein kinases pathway, intedeukin-6/the activator of transcription 3 pathway and epidermal growth factor receptor pathway, as well as the expression dysregulation of the proinflamma- tory factors and inflammatory suppressors. This review will provide insights into the prevention of CRC.