摘要
长链非编码RNA（lncRNAs）是长度在200~100 000核苷酸的非编码RNA分子,曾被认为是DNA转录的“噪音”,不具备生物学功能。近年研究表明lncRNAs广泛参与基因沉默、转录激活、细胞周期和分化、染色体构型修饰等众多生理功能,成为肿瘤研究领域的新热点。本文对lncRNAs在乳腺癌发生、进展、分子分型、治疗抵抗、上皮间质转化以及外泌体中表达作一系统阐述,将为深入理解lncRNAs在乳腺癌发生、发展中的精细分子调控机制以及探索乳腺癌新的诊断和特异性治疗靶点开拓思路。
Long noncoding RNAs（lncRNAs） refer to non-coding RNA molecules with the length between 200-100 000 nucle- otides. They were considered as transcriptional＇ noise＇ without biological function. However, recent studies show that IncRNAs have a wide participation in gene silencing, transcriptional activation, cell cycle and differentiation, chromosome configuration modification, and many other biological functions, making lneRNAs a new hot spot in the field of eaneer research. In this review, we give a systemat- ic description of the relationship between lncRNAs and breast cancer carcinogenesis, progression, molecular subtyping, treatment re- sistance, epithelial-mesenchymal transition and exosomes. We hope that this review will help to promote a better understanding of the sophisticated molecular regulation mechanisms of lncRNAs in breast cancer development and pioneer new ideas for diagnostic methods and speeiiie therapeutic targets for breast cancer.
出处
《临床肿瘤学杂志》
CAS
2016年第8期736-743,共8页
Chinese Clinical Oncology
基金
国家自然科学基金资助项目(81301858)
