转移相关基因-2调控肿瘤侵袭转移的研究

Research on metastasis associated gene 2 mediating invasion and metastasis of tumor

转移相关基因-2(MTA2)是转移相关基因家族成员之一,其蛋白质序列及功能结构域编码序列与MTA1具有高度同源性。MTA2参与构成核小体重构及组蛋白去乙酰化酶(NuRD)复合物,并可与多种转录因子相互作用,参与基因转录调控。MTA2在多种恶性肿瘤中异常表达,并与肿瘤恶性生物学行为密切相关,提示MTA2在肿瘤发生、发展过程中发挥重要作用。本文将对MTA2在肿瘤中的表达情况、生物学功能以及在肿瘤侵袭、转移中的相关分子机制等进行综述。

Metastasis associated gene 2 （MTA2） is a member of metastasis-associated gene family. Protein alignment homology of human MTA proteins and coding sequence of functional domain revealed high homology of MTA2 with MTA1. MTA2 is one of the components of nucleosome remodeling deaeetylase （NuRD） complex which have chromatin remodeling and histone deaeetylating properties. It can also interact with some transcription factors and involve into gene transcriptional regulation. MTA2 is over-expressed in various kinds of malignancies and closely associated with tumor invasion and metastasis, which indicates that MTA2 may play vital role in tumor metastasis. Herein, we will review the expression, biological function and the molecular mechanism of MTA2 in tumor invasion and metastasis.