长链非编码RNA在食管癌中的研究进展

Progress of long non-coding RNA in esophageal carcinoma

随着分子生物学研究技术的革新和计算机生物信息学的出现和蓬勃发展,长链非编码RNA(lncRNA)的作用和生物学功能得到了深入研究,其在基因的转录翻译、细胞分化、个体发育、遗传及表观遗传等生命活动中具有重要的调控作用。目前,已有众多权威研究证实lncRNA可在表观遗传学、转录水平、转录后水平与DNA、RNA、蛋白质分子相互结合,在多个重要节点调控肿瘤的进展。lncRNA异常表达与肿瘤的发生、发展和转移均密切相关。本文着重强调lncRNA主要生物学功能,并总结其在食管癌中的异常表达及其调控作用,以期为食管癌的诊断和治疗提供新思路。

With the innovations sequencing technologies, biotechnology and computational biology, long noncoding RNAs （ln- cRNAs） are being identified and characterized at a rapid pace. Recent findings reveal that lncRNAs are implicated a series of cancer development. These lncRNAs interact with DNA, RNA, protein molecules and/or their combinations, acting as an essential regulator in chromatin organization, and transcriptional and post-transcriptional regulation. Their abnormal expression confers the cancer cell ac- tivities for tumor initiation, growth and metastasis. This review here will emphasize their aberrant expression and function in cancer, and the roles in cancer diagnosis and therapy will also be discussed. LncRNAs have emerged as an essential regulator in almost all as- pects of biology. Accumulating evidence suggests that lncRNAs play an important role in tumorigenesis. In this review, we will briefly review the structure and function of lneRNAs, and then emphasize their aberrant expression and their functional roles in esophageal carcinoma, diagnosis and therapy.